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Old Dominion vs. Southern Miss prediction: Southern Miss favored to win men's college basketball matchup [2/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Old Dominion vs Southern Miss predictions for college basketball Saturday.
Southern Miss will face Old Dominion in men's college basketball action at Reed Green Coliseum on Saturday, starting at 3:00 PM ET.
Based on updated simulation results, Dimers' advanced college basketball model projects Southern Miss as the most likely winner of the Old Dominion vs. Southern Miss game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Old Dominion vs. Southern Miss prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Saturday's NCAA basketball matchup between Old Dominion and Southern Miss 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Southern Miss a 68% chance of defeating Old Dominion. Our predicted final score has Southern Miss winning 77-72.
According to our model, Southern Miss (-4.5) has a 53% chance of covering the spread, while the 148.5-point over/under has a 52% chance of going over.
Old Dominion vs. Southern Miss odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Old Dominion | Southern Miss |
|---|---|---|
| Spread | +4.5 (-112) | -4.5 (-105) |
| Moneyline | +172 | -190 |
| Total | o148.5 (-106) | u148.5 (-114) |
All odds are correct at the time of publication and are subject to change.
Old Dominion vs. Southern Miss picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Miss -4.5 | -105 |
| Moneyline | Southern Miss | -190 |
| Total | Over 148.5 | -106 |
According to our men's college basketball best bets, the top play to make on this game is Southern Miss to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Old Dominion vs. Southern Miss game-day updates and essential details
Saturday's men's college basketball action between Southern Miss and Old Dominion at Reed Green Coliseum is scheduled to begin at 3:00 PM ET.
- Who: Old Dominion vs. Southern Miss
- Date: Saturday, February 21, 2026
- Time: 3:00 PM ET/12:00PM PT
- Venue: Reed Green Coliseum
Conclusion
We predict Southern Miss, with a 68% win probability, will likely beat Old Dominion on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Old Dominion vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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