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Mississippi State vs. South Carolina prediction: Mississippi State favored to win men's college basketball matchup [2/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Mississippi State vs South Carolina predictions for college basketball Saturday.
South Carolina will take on Mississippi State in men's college basketball action at Colonial Life Arena on Saturday, beginning at 1:00 PM ET.
Based on the latest simulation results, Dimers' advanced college basketball model predicts Mississippi State as the most likely winner of the Mississippi State vs. South Carolina game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Mississippi State vs. South Carolina prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball game between Mississippi State and South Carolina 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives Mississippi State a 55% chance of beating South Carolina. Our predicted final score has Mississippi State winning 77-75.
According to our model, South Carolina (+1.5) has a 51% chance of covering the spread, while the 152.5-point over/under has a 52% chance of going over.
Mississippi State vs. South Carolina odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Mississippi State | South Carolina |
|---|---|---|
| Spread | -1.5 (+100) | +1.5 (-118) |
| Moneyline | -115 | -102 |
| Total | o152.5 (-110) | u152.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Mississippi State vs. South Carolina picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Mississippi State -1.5 | +100 |
| Moneyline | Mississippi State | -115 |
| Total | Over 152.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Mississippi State to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Mississippi State vs. South Carolina game-day updates and essential details
Saturday's men's college basketball action between South Carolina and Mississippi State at Colonial Life Arena is scheduled to commence at 1:00 PM ET.
- Who: Mississippi State vs. South Carolina
- Date: Saturday, February 21, 2026
- Time: 1:00 PM ET/10:00AM PT
- Venue: Colonial Life Arena
Conclusion
We predict Mississippi State, with a 55% win probability, will likely beat South Carolina on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Mississippi State vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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