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Michigan State vs. DePaul prediction: Michigan State favored to win women's college basketball matchup [12/14/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Michigan State vs DePaul predictions for college basketball Sunday.
DePaul will square off with Michigan State in women's college basketball action at Wintrust Arena on Sunday, starting at 5:30PM ET.
Based on the latest simulation results, Dimers' new women's basketball model projects Michigan State as the most likely winner of the Michigan State vs. DePaul game.
This article offers a closer look at Sunday's matchup, including best bets and picks.
Michigan State vs. DePaul prediction: Who will win?
Using powerful machine learning and data analysis, we have simulated the outcome of Sunday's women's basketball matchup between Michigan State and DePaul 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model currently gives Michigan State a 98% chance of defeating DePaul.
According to our model, the over/under total of 143.5 points has a 55% chance of going over.
Michigan State vs. DePaul odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Michigan State | DePaul |
|---|---|---|
| Spread | -32.5 (-115) | +32.5 (-105) |
| Total | o143.5 (-110) | u143.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Michigan State vs. DePaul picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +32.5 | -105 |
| Total | Over 143.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is over 143.5 points.
Michigan State vs. DePaul game-day updates and essential details
Sunday's women's basketball game between DePaul and Michigan State at Wintrust Arena is scheduled to begin at 5:30PM ET.
- Who: Michigan State vs. DePaul
- Date: Sunday, December 14, 2025
- Time: 5:30PM ET/2:30PM PT
- Venue: Wintrust Arena
Conclusion
We predict Michigan State, with a 98% win probability, will likely beat DePaul on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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