Michigan State vs. DePaul prediction: Michigan State favored to win women's college basketball matchup [12/14/2025]

DePaul will square off with Michigan State in women's college basketball action at Wintrust Arena on Sunday, starting at 5:30PM ET.

Based on the latest simulation results, Dimers' new women's basketball model projects Michigan State as the most likely winner of the Michigan State vs. DePaul game.

This article offers a closer look at Sunday's matchup, including best bets and picks.

Michigan State vs. DePaul prediction: Who will win?

Using powerful machine learning and data analysis, we have simulated the outcome of Sunday's women's basketball matchup between Michigan State and DePaul 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model currently gives Michigan State a 98% chance of defeating DePaul.

According to our model, the over/under total of 143.5 points has a 55% chance of going over.

Michigan State vs. DePaul odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Michigan State vs. DePaul picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: