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Loyola Chicago vs. Saint Joseph's (PA) prediction: Saint Joseph's (PA) favored to win men's college basketball matchup [2/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Loyola Chicago vs Saint Joseph's (PA) predictions for college basketball Saturday.
Men's college basketball action continues on Saturday at 12:00 PM ET as Loyola Chicago takes on Saint Joseph's (PA) in men's college basketball action at Michael J. Hagan '85 Arena.
Based on the latest simulation results, Dimers' advanced college basketball model projects Saint Joseph's (PA) as the most likely winner of the Loyola Chicago vs. Saint Joseph's (PA) game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Loyola Chicago vs. Saint Joseph's (PA) prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Loyola Chicago and Saint Joseph's (PA) 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Saint Joseph's (PA) an 83% chance of defeating Loyola Chicago. Our predicted final score has Saint Joseph's (PA) winning 78-68.
According to our model, Saint Joseph's (PA) (-9.5) has a 55% chance of covering the spread, while the 142.5-point over/under has a 56% chance of going over.
Loyola Chicago vs. Saint Joseph's (PA) odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Loyola Chicago | Saint Joseph's (PA) |
|---|---|---|
| Spread | +9.5 (-115) | -9.5 (-105) |
| Moneyline | +385 | -475 |
| Total | o142.5 (-105) | u142.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Loyola Chicago vs. Saint Joseph's (PA) picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Saint Joseph's (PA) -9.5 | -105 |
| Moneyline | Saint Joseph's (PA) | -475 |
| Total | Over 142.5 | -105 |
According to our best men's college basketball bets, the top play to make on this game is Over 142.5 total points.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Loyola Chicago vs. Saint Joseph's (PA) game-day updates and essential details
Saturday's men's college basketball game between Saint Joseph's (PA) and Loyola Chicago at Michael J. Hagan '85 Arena is scheduled to start at 12:00 PM ET.
- Who: Loyola Chicago vs. Saint Joseph's (PA)
- Date: Saturday, February 21, 2026
- Time: 12:00 PM ET/9:00AM PT
- Venue: Michael J. Hagan '85 Arena
Conclusion
We predict Saint Joseph's (PA), with an 83% win probability, will likely beat Loyola Chicago on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Loyola Chicago vs. Saint Joseph's (PA) insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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