Arizona Cardinals vs. Cincinnati Bengals: Experts release early Week 17 predictions [2025]

The Arizona Cardinals and Cincinnati Bengals will meet in Week 17 of the NFL season at Paycor Stadium on Sunday, December 28, 2025, starting at 1:00 PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bengals as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cardinals vs. Bengals predictions page.

Arizona vs. Cincinnati early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cardinals vs. Bengals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cardinals 34%, Bengals 66%
• Predicted final score: Cardinals 23-27 Bengals
• Spread: Cardinals (+5.5) 54%, Bengals (-5.5) 46%
• Total points (50.5): Over 53%, Under 47%

As of December 22, 2025, these Cardinals-Bengals calculations and predictions reflect the latest data and insights available.

Cardinals vs. Bengals Week 17 details

The NFL Week 17 matchup between the Bengals and Cardinals at Paycor Stadium is scheduled for December 28, 2025.

• Who: Arizona Cardinals vs. Cincinnati Bengals
• Date: Sunday, December 28, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Paycor Stadium

Cardinals vs. Bengals opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Cardinals +5.5 (-110), Bengals -5.5 (-110)
• Moneyline: Cardinals +210, Bengals -238
• Total: Over/Under 50.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 17 betting promos and codes

Make the most of Dimers' Cardinals vs. Bengals predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Bengals, with a 66% win probability, will likely beat the Cardinals in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Bengals matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.