Anastasia Zakharova vs. Camila Osorio prediction, odds, picks for WTA Madrid Open 2026

Anastasia Zakharova and Camila Osorio will meet in the round of 128 of the WTA Madrid Open event on Tuesday.

Based on updated simulations, Dimers' proven tennis model projects Camila Osorio as the most likely winner of the Zakharova vs. Osorio match.

This article offers an expanded analysis of Tuesday's match, including best bets and picks.

Zakharova vs. Osorio prediction: Who will win and advance to the second round?

Using powerful machine learning and data, we have simulated the result of Tuesday's Zakharova-Osorio women's singles match, forming part of our tennis predictions coverage.

Our independent predictive model gives Osorio a 70% chance of defeating Zakharova at the WTA Madrid Open tournament.

Additionally, Osorio has a 66% chance of winning the first set. The simulations also show Zakharova (+4.5) has a 53% chance of covering the games spread, while the over 20.5 games has a 52% chance of hitting, according to our model.

Anastasia Zakharova vs. Camila Osorio odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

Zakharova vs. Osorio picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our tennis best bets, the top play to make on this match is Anastasia Zakharova to win.

Although Zakharova is less than likely to win, she provides the best value at the current available odds.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Zakharova vs. Osorio updates and essential details

The WTA Madrid Open match between Anastasia Zakharova and Camila Osorio is scheduled to start on Tuesday at 12:00 PM ET.

• Who: Anastasia Zakharova vs. Camila Osorio
• Date: Tuesday, April 21, 2026
• Approx. Time: 12:00 PM ET/9:00AM PT
• Tournament: WTA Madrid, Spain Women's Singles 2026
• Round: Round of 128

All dates and times in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Camila Osorio, with a 70% win probability, will likely beat Anastasia Zakharova at the WTA Madrid Open tournament.

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