Wisconsin vs. Notre Dame prediction: Notre Dame favored to win in college football Week 1 [2026]

Notre Dame and Wisconsin will clash in Week 1 college football action at Lambeau Field on Sunday, with kickoff at 7:30 PM ET.

Dimers' proven college football model projects Notre Dame as the most likely winner in this Wisconsin vs. Notre Dame prediction.

This article offers further insights into Sunday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Wisconsin vs. Notre Dame prediction and odds

Using powerful machine learning and data, we have simulated the result of Wisconsin vs. Notre Dame, forming part of our college football predictions coverage.

Our famous predictive model gives Notre Dame a 93.0% chance of defeating Wisconsin. Our predicted final score has Notre Dame winning 34-13.

According to our model, Wisconsin (+22.5) has a 55.6% chance of covering the spread, while the 46.5-point over/under has a 55.1% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Wisconsin +22.5 (-115) / Notre Dame -22.5 (-102)
• Moneyline: Wisconsin +1100, Notre Dame -1650
• Total: Over/Under 46.5 (-107/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Wisconsin +22.5 @ -115 via ESPN BET
• Moneyline: Notre Dame @ -1650 via DraftKings
• Total: Over 46.5 @ -107 via Caesars

According to our college football best bets, the top play to make on this game is Over 46.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Sunday's college football game between Notre Dame and Wisconsin at Lambeau Field is scheduled to commence at 7:30 PM ET.

• Who: Wisconsin vs. Notre Dame
• Date: Sunday, September 6, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Lambeau Field

College football Week 1 promos

Make the most of Dimers' Wisconsin vs. Notre Dame predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Notre Dame, with a 93.0% win probability, will likely beat Wisconsin in Sunday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.