Southeast Missouri State vs. Eastern Illinois prediction: Why Southeast Missouri State is favored to win in college football Week 8 [2026]

Using innovative machine learning and data analysis, we have re-simulated the result of Southeast Missouri State vs. Eastern Illinois, forming part of our college football predictions coverage.

Our leading predictive model gives Southeast Missouri State a 68.2% chance of beating Eastern Illinois. Our predicted final score has Southeast Missouri State winning 27-22. According to our model, Eastern Illinois (+7) has a 54.4% chance of covering the spread, while the 49.5-point over/under has a 51.5% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southeast Missouri State -7 (-112) / Eastern Illinois +7 (-110)
• Moneyline: Southeast Missouri State -251, Eastern Illinois +233
• Total: Over/Under 49.5 (-106/-102)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Eastern Illinois +7 @ -110 via DraftKings
• Moneyline: Eastern Illinois @ 30¢ via Novig
• Total: Over 49.5 @ 51¢ via Novig

According to our college football best bets, the top play to make on this game is Eastern Illinois +7 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Eastern Illinois and Southeast Missouri State at O'Brien Field is scheduled to commence at 3:00 PM ET.

• Who: Southeast Missouri State vs. Eastern Illinois
• Date: Saturday, October 24, 2026
• Time: 3:00 PM ET/12:00 PM PT
• Venue: O'Brien Field

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Conclusion

We predict Southeast Missouri State, with a 68.2% win probability, will likely beat Eastern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.