College football picks today: Week 2 Saturday best bets highlight Cal Poly vs. San Jose State play [9/12/2026]

Today’s college football picks for September 12, 2026 are here, with Cal Poly vs. San Jose State among the top plays identified by our model across Saturday’s college football schedule.

Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to unearth legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [9/12, updated 8:36PM ET]

Below, you’ll find today’s college football best bets, ranked by edge for Saturday, September 12, 2026.

Cal Poly +21.5 (-106)

• Edge: 3.7%
• Probability: 55.2%
• Matchup: Cal Poly vs. San Jose State (9:00PM ET)

Our model has identified value on Cal Poly +21.5 at -106 odds. A 55.2% probability produces an edge of 3.7%, making this the strongest play for today's college football slate.

NCAAF best bets summary: Saturday, 9/12/2026

As of 8:36PM ET, here is our top college football bet by edge recommended by our model:

List of upcoming college football games to bet on now

• Cal Poly vs. San Jose State (9:00PM ET, Saturday)
• Texas Southern vs. Texas-El Paso (9:00PM ET, Saturday)
• North Dakota State vs. Air Force (10:00PM ET, Saturday)
• North Dakota vs. Portland State (10:00PM ET, Saturday)
• Arkansas vs. Utah (10:15PM ET, Saturday)
• Sacramento State vs. Fresno State (10:30PM ET, Saturday)
• Montana State vs. Nevada (10:30PM ET, Saturday)
• Louisiana-Lafayette vs. Southern California (11:00PM ET, Saturday)
• New Mexico State vs. Hawaii (12:00AM ET, Sunday)

College football offer for Week 2

Make the most of the picks in this article—including Cal Poly +21.5—with the Bet365 Sportsbook offer below:

Conclusion

Our college football best bets are locked and loaded for September 12, 2026, featuring plays such as Cal Poly +21.5 vs. San Jose State. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.