Matteo Berrettini vs. Mariano Navone prediction, odds, picks for US Open 2026

Matteo Berrettini will square off with Mariano Navone in the second round of the US Open Men's Singles 2026 on Wednesday.

Dimers' advanced tennis model projects Matteo Berrettini as the most likely winner in this Berrettini vs. Navone prediction.

This article offers an expanded analysis of Wednesday's match, including best bets and picks.

Berrettini vs. Navone prediction and odds

Using trusted machine learning and data, we have simulated the outcome of Wednesday's Berrettini-Navone men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model gives Berrettini a 66% chance of defeating Navone in the US Open 2026.

Latest betting odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Mariano Navone +158, Matteo Berrettini -189

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Berrettini @ -189 via DraftKings
• First Set: Navone @ -135 via DraftKings

According to our tennis best bets, the top play to make on this match is Matteo Berrettini to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The US Open 2026 match between Matteo Berrettini and Mariano Navone is scheduled to start on Wednesday at 2:20 PM ET.

• Who: Matteo Berrettini vs. Mariano Navone
• Date: Wednesday, September 2, 2026
• Approx. Time: 2:20 PM ET/11:20AM PT
• Tournament: US Open Men's Singles 2026
• Round: Second round

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Matteo Berrettini, with a 66% win probability, will likely beat Mariano Navone at the US Open 2026.

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