Alexei Popyrin vs. Alejandro Tabilo prediction, odds, picks for US Open 2026

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's Popyrin-Tabilo men's singles match, forming part of our tennis predictions coverage.

Our independent predictive model currently gives Tabilo a 54% chance of winning against Popyrin in the US Open 2026.

Alexei Popyrin vs. Alejandro Tabilo odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Alejandro Tabilo -136, Alexei Popyrin +116

All odds are correct at the time of publication and are subject to change.

Popyrin vs. Tabilo picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Popyrin @ +116 via DraftKings
• First Set: Tabilo @ -135 via DraftKings

According to our tennis best bets, the top play to make on this match is Alexei Popyrin to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Popyrin vs. Tabilo updates and essential details

The US Open 2026 match between Alexei Popyrin and Alejandro Tabilo is scheduled to start on Wednesday at 11:00 AM ET.

• Who: Alexei Popyrin vs. Alejandro Tabilo
• Date: Wednesday, September 2, 2026
• Approx. Time: 11:00 AM ET/8:00AM PT
• Tournament: US Open Men's Singles 2026
• Round: Second round

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Alejandro Tabilo, with a 54% win probability, will likely beat Alexei Popyrin at the US Open 2026.

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