Colts vs. Chiefs: NFL Week 2 Prediction, Picks & Odds

Dimers' Colts vs. Chiefs prediction for Sunday, September 20, 2026. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
FINAL
NFL
FINAL
NFL sport icon
NFL
Colts
30
33
Arrowhead Stadium
Chiefs
Arrowhead Stadium
Live Probabilities
Win %
  • Colts
    0%
  • Chiefs
    100%
Win Probability
TEAM1234OTT
Colts
7 13 0 7 3 30
Chiefs
10 7 7 3 6 33
1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0 1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0
Chiefs
Colts
1st and 10 at the IND 22
Last Play
End Game

Colts vs. Chiefs: Detailed Breakdown

Matchup overview: NFL Week 2

  • Teams: Indianapolis Colts vs. Kansas City Chiefs
  • Date: Sunday, September 20, 2026
  • Time: 8:20PM ET
  • Venue: Arrowhead Stadium

Current betting odds

  • Spread: Colts (+6.5, +100), Chiefs (-6.5, -102)
  • Moneyline: Colts +270, Chiefs -270
  • Total (Over/Under): 46.5 points (+104/-106)

Dimers’ win probabilities

  • Colts: 31.1%
  • Chiefs: 68.9%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Colts 19-25 Chiefs.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models

Our Prediction: Who Wins?

The numbers give the Colts a win probability of 31.1%, while the Chiefs have a win probability of 68.9%.

Summary

The Colts face off against the Chiefs in the NFL at Arrowhead Stadium on Sunday, September 20, 2026.

Our Colts vs. Chiefs predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.