Colts vs. Chiefs: NFL Week 2 Prediction, Picks & Odds

Dimers' Colts vs. Chiefs prediction for Sunday, September 20, 2026. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
NFL
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NFL
Colts
Predicted score
20
:
26
Arrowhead Stadium
Chiefs
Arrowhead Stadium
Pre-Game Probabilities Last Update:

Spread

Colts +6.5
Spread
  • Colts
    52.4%
    DraftKingsDraftKings
  • Chiefs
    47.6%
    NovigNovig
Player Props
Colts
Probability
  • Jonathan Taylor
    57.5%
  • Alec Pierce
    30.4%
  • Tyler Warren
    30.2%
  • Josh Downs
  • Keenan Allen
Chiefs
Probability
  • Kenneth Walker
    49.4%
  • Rashee Rice
    28.8%
  • Xavier Worthy
    21.6%
  • Travis Kelce
  • Tyquan Thornton
Projected Player Stats
Colts Starting QB
PlayerProj. Yards
D. Jones
Chiefs Starting QB
PlayerProj. Yards
P. Mahomes
Colts Rushing
PlayerTouchdown %TD%Proj. Yards
J. Taylor
D. Jones
S. McGowan
Chiefs Rushing
PlayerTouchdown %TD%Proj. Yards
K. Walker
E. Johnson
P. Mahomes
Colts Receiving
PlayerTouchdown %TD%Proj. Yards
A. Pierce
J. Downs
T. Warren
K. Allen
J. Taylor
Chiefs Receiving
PlayerTouchdown %TD%Proj. Yards
R. Rice
X. Worthy
T. Kelce
T. Thornton
K. Walker

Colts vs. Chiefs: Detailed Breakdown

Matchup overview: NFL Week 2

  • Teams: Indianapolis Colts vs. Kansas City Chiefs
  • Date: Sunday, September 20, 2026
  • Time: 8:20PM ET
  • Venue: Arrowhead Stadium

Current betting odds

  • Spread: Colts (+6.5, +100), Chiefs (-6.5, -104)
  • Moneyline: Colts +277, Chiefs -285
  • Total (Over/Under): 47.5 points (+100/-110)

Dimers’ win probabilities

  • Colts: 29.9%
  • Chiefs: 70.1%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Colts 20-26 Chiefs.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.

Our Prediction: Who Wins?

The numbers give the Colts a win probability of 29.9%, while the Chiefs have a win probability of 70.1%.

Summary

The Colts face off against the Chiefs in the NFL at Arrowhead Stadium on Sunday, September 20, 2026.

Our Colts vs. Chiefs predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.