San Francisco vs. Santa Clara prediction: Santa Clara favored to win men's college basketball matchup [1/28/2026]

Santa Clara will square off with San Francisco in men's college basketball action at Leavey Center on Wednesday, beginning at 11:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Santa Clara as the most likely winner of the San Francisco vs. Santa Clara game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

San Francisco vs. Santa Clara prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between San Francisco and Santa Clara 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Santa Clara an 83% chance of defeating San Francisco. Our predicted final score has Santa Clara winning 80-70.

According to our model, Santa Clara (-9.5) has a 55% chance of covering the spread, while the over/under total of 150.5 points has a 51% chance of staying under.

San Francisco vs. Santa Clara odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

San Francisco vs. Santa Clara picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Santa Clara -9.5 at the spread.

San Francisco vs. Santa Clara game-day updates and essential details

Wednesday's men's college basketball game between Santa Clara and San Francisco at Leavey Center is scheduled to start at 11:00 PM ET.

• Who: San Francisco vs. Santa Clara
• Date: Wednesday, January 28, 2026
• Time: 11:00 PM ET/8:00PM PT
• Venue: Leavey Center

Conclusion

We predict Santa Clara, with an 83% win probability, will likely beat San Francisco on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate San Francisco vs. Santa Clara insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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