Ohio State vs. Penn State prediction: Why Ohio State is favored to win men's college basketball matchup [3/4/2026]

Penn State will square off with the favored Ohio State in men's college basketball action at Bryce Jordan Center on Wednesday, commencing at 7:30 PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts Ohio State as the most likely winner of the Ohio State vs. Penn State game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Ohio State vs. Penn State prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between Ohio State and Penn State 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Ohio State a 72% chance of beating Penn State. Our predicted final score has Ohio State winning 79-73.

According to our model, Penn State (+7.5) has a 55% chance of covering the spread, while the 152.5-point over/under has an equal 50-50 chance of hitting.

Ohio State vs. Penn State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type	Ohio State	Penn State
Spread	-7.5 (-102)	+7.5 (-115)
Moneyline	-300	+265
Total	o152.5 (-115)	u152.5 (-105)

All odds are correct at the time of publication and are subject to change.

Ohio State vs. Penn State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Penn State +7.5	-115
Moneyline	Penn State	+265
Total	Under 152.5	-105

According to our men's college basketball best bets, the top play to make on this game is Penn State +7.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Ohio State vs. Penn State game-day updates and essential details

Wednesday's men's college basketball game between Penn State and Ohio State at Bryce Jordan Center is scheduled to commence at 7:30 PM ET.

• Who: Ohio State vs. Penn State
• Date: Wednesday, March 4, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Bryce Jordan Center

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Conclusion

We predict Ohio State, with a 72% win probability, will likely beat Penn State on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Ohio State vs. Penn State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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