Southern Miss vs. Auburn prediction: Why Auburn is favored to win in college football Week 2 [2026]

Auburn will take on Southern Miss in Week 2 college football action at Jordan-Hare Stadium on Saturday, starting at 7:45 PM ET.

Dimers' proven college football model projects Auburn as the most likely winner in this Southern Miss vs. Auburn prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Southern Miss vs. Auburn prediction and odds

Using innovative machine learning and statistical analysis, we have re-simulated the result of Southern Miss vs. Auburn, forming part of our college football predictions coverage.

Our leading predictive model gives Auburn a 98.3% chance of defeating Southern Miss. Our predicted final score has Auburn winning 43-12. According to our model, Southern Miss (+34.5) has a 57.5% chance of covering the spread, while the 56.5-point over/under has a 50.1% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southern Miss +34.5 (-115) / Auburn -34.5 (-105)
• Moneyline: Southern Miss +3500, Auburn -8000
• Total: Over/Under 56.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Miss +34.5 @ -115 via ESPN BET
• Moneyline: Auburn @ -8000 via FanDuel
• Total: Under 56.5 @ -110 via Caesars

According to our college football best bets, the top play to make on this game is Southern Miss +34.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Auburn and Southern Miss at Jordan-Hare Stadium is scheduled to begin at 7:45 PM ET.

• Who: Southern Miss vs. Auburn
• Date: Saturday, September 12, 2026
• Time: 7:45 PM ET/4:45PM PT
• Venue: Jordan-Hare Stadium

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Conclusion

We predict Auburn, with a 98.3% win probability, will likely beat Southern Miss in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.