Southeast Missouri State vs. Southern Illinois prediction favors Southern Illinois to win in college football Week 2 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Southeast Missouri State vs. Southern Illinois, forming part of our college football predictions coverage.

Our independent predictive model currently gives Southern Illinois a 76.6% chance of defeating Southeast Missouri State. Our predicted final score has Southern Illinois winning 30-22. According to our model, Southern Illinois (-7.5) has a 51.8% chance of covering the spread, while the over/under total of 53 points has a 51.2% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southeast Missouri State +7.5 (-110) / Southern Illinois -7.5 (-110)
• Moneyline: Southeast Missouri State +266, Southern Illinois -305
• Total: Over/Under 53 (+100/-120)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Illinois -7.5 @ -110 via bet365
• Moneyline: Southern Illinois @ -305 via bet365
• Total: Over 53 @ +100 via bet365

According to our college football best bets, the top play to make on this game is Southern Illinois to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Southern Illinois and Southeast Missouri State at Saluki Stadium is scheduled to start at 7:00 PM ET.

• Who: Southeast Missouri State vs. Southern Illinois
• Date: Saturday, September 12, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Saluki Stadium

College football Week 2 promos

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Conclusion

We predict Southern Illinois, with a 76.6% win probability, will likely beat Southeast Missouri State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.