Southeast Missouri State vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 1 [2026]

Using trusted machine learning and data, we have simulated the result of Southeast Missouri State vs. Iowa State, forming part of our college football predictions coverage.

Our famous predictive model gives Iowa State a 98.0% chance of defeating Southeast Missouri State. Our predicted final score has Iowa State winning 40-10.

According to our model, the bookmakers have got it right, and Southeast Missouri State and Iowa State each have a 50% chance of covering the spread, while the over/under total of 53.5 points has a 57.9% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Southeast Missouri State +30.5 (-110) / Iowa State -30.5 (-105)
• Moneyline: Southeast Missouri State +4000, Iowa State -8000
• Total: Over/Under 53.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Iowa State -30.5 @ -105 via ESPN BET
• Moneyline: Southeast Missouri State @ +4000 via DraftKings
• Total: Under 53.5 @ -110 via ESPN BET

According to our college football best bets, the top play to make on this game is Under 53.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Iowa State and Southeast Missouri State at Jack Trice Stadium is scheduled to commence at 1:00 PM ET.

• Who: Southeast Missouri State vs. Iowa State
• Date: Saturday, September 5, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Jack Trice Stadium

College football Week 1 promos

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Conclusion

We predict Iowa State, with a 98.0% win probability, will likely beat Southeast Missouri State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.