Rice vs. Notre Dame prediction favors Notre Dame to win in college football Week 2 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Rice vs. Notre Dame, forming part of our college football predictions coverage.

Our independent predictive model currently gives Notre Dame a 99.8% chance of beating Rice. Our predicted final score has Notre Dame winning 49-5. According to our model, Rice (+45) has a 54.7% chance of covering the spread, while the 53.5-point over/under has a 53.1% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Rice +45 (-107) / Notre Dame -45 (-113)
• Moneyline: Rice , Notre Dame

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Over @ -110 via Bet365

According to our college football best bets, the top play to make on this game is Rice +45.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Notre Dame and Rice at Notre Dame Stadium is scheduled to start at 3:30 PM ET.

• Who: Rice vs. Notre Dame
• Date: Saturday, September 12, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Notre Dame Stadium

College football Week 2 promos

Make the most of Dimers' Rice vs. Notre Dame predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Notre Dame, with a 99.8% win probability, will likely beat Rice in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.