Ohio vs. Nebraska prediction: Nebraska favored to win in college football Week 1 [2026]

Nebraska will square off with Ohio in Week 1 college football action at Memorial Stadium on Saturday, with kickoff at 12:00 PM ET.

Dimers' advanced college football model projects Nebraska as the most likely winner in this Ohio vs. Nebraska prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Ohio vs. Nebraska prediction and odds

Using trusted machine learning and data, we have simulated the outcome of Ohio vs. Nebraska, forming part of our college football predictions coverage.

Our famous predictive model gives Nebraska a 95.4% chance of defeating Ohio. Our predicted final score has Nebraska winning 35-11.

According to our model, Nebraska (-17.5) has a 63.4% chance of covering the spread, while the over/under total of 58 points has a 76.1% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Ohio +17.5 (-118) / Nebraska -17.5 (-121)
• Moneyline: Ohio +1300, Nebraska -1750
• Total: Over/Under 58 (-121/-118)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Nebraska -17.5 @ -121 via BetRivers
• Moneyline: Nebraska @ -1750 via DraftKings
• Total: Under 58 @ -118 via BetRivers

According to our college football best bets, the top play to make on this game is Under 58 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Nebraska and Ohio at Memorial Stadium is scheduled to start at 12:00 PM ET.

• Who: Ohio vs. Nebraska
• Date: Saturday, September 5, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Memorial Stadium

College football Week 1 promos

Make the most of Dimers' Ohio vs. Nebraska predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Nebraska, with a 95.4% win probability, will likely beat Ohio in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.