Jacksonville State vs. Ohio prediction favors Ohio to win in college football Week 2 [2026]

Ohio and Jacksonville State will lock horns in Week 2 college football action at Frank Solich Field at Peden Stadium on Saturday, starting at 6:00 PM ET.

Dimers' advanced college football model gives Ohio a slight edge with a 53.8% win probability over Jacksonville State.

This article offers a complete Jacksonville State vs. Ohio prediction, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Jacksonville State vs. Ohio prediction and odds

Using trusted machine learning and data, we have re-simulated the outcome of Jacksonville State vs. Ohio, forming part of our college football predictions coverage.

Our famous predictive model gives Ohio a 53.8% chance of beating Jacksonville State. Our predicted final score has Ohio winning 26-24. According to our model, Ohio (-2.5) has a 50.3% chance of covering the spread, while the over/under total of 48.5 points has a 56.0% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Jacksonville State +2.5 (-105) / Ohio -2.5 (-115)
• Moneyline: Jacksonville State +115, Ohio -120
• Total: Over/Under 48.5 (-112/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Jacksonville State +2.5 @ -105 via ESPN BET
• Moneyline: Ohio @ -120 via FanDuel
• Total: Over 48.5 @ -112 via DraftKings

According to our college football best bets, the top play to make on this game is Over 48.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Ohio and Jacksonville State at Frank Solich Field at Peden Stadium is scheduled to commence at 6:00 PM ET.

• Who: Jacksonville State vs. Ohio
• Date: Saturday, September 12, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Frank Solich Field at Peden Stadium

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Conclusion

We predict Ohio, with a 53.8% win probability, will likely beat Jacksonville State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.