Holy Cross vs. Colgate prediction: Why Colgate is favored to win in college football Week 1 [2026]

Colgate will take on Holy Cross in Week 1 college football action at Crown Field at Andy Kerr Stadium on Saturday, beginning at 1:00 PM ET.

Dimers' advanced college football model projects Colgate as the most likely winner in this Holy Cross vs. Colgate prediction.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Holy Cross vs. Colgate prediction and odds

Using powerful machine learning and statistical analysis, we have simulated the outcome of Holy Cross vs. Colgate, forming part of our college football predictions coverage.

Our famous predictive model gives Colgate a 63.9% chance of beating Holy Cross. Our predicted final score has Colgate winning 26-21.

According to our model, the bookmakers have got it right, and Holy Cross and Colgate each have a 50% chance of covering the spread, while the 49.5-point over/under has a 52.4% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +4.5 (-105) / Colgate -4.5 (-110)
• Moneyline: Holy Cross +156, Colgate -185
• Total: Over/Under 49.5 (-110/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +4.5 @ -105 via bet365
• Moneyline: Colgate @ -185 via bet365
• Total: Under 49.5 @ -105 via bet365

According to our college football best bets, the top play to make on this game is Under 49.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Colgate and Holy Cross at Crown Field at Andy Kerr Stadium is scheduled to commence at 1:00 PM ET.

• Who: Holy Cross vs. Colgate
• Date: Saturday, September 5, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Crown Field at Andy Kerr Stadium

College football Week 1 promos

Make the most of Dimers' Holy Cross vs. Colgate predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Colgate, with a 63.9% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.