Charlotte vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 2 [2026]

Mississippi will face Charlotte in Week 2 college football action at Vaught-Hemingway Stadium on Saturday, starting at 7:45 PM ET.

Dimers' proven college football model projects Mississippi as the most likely winner in this Charlotte vs. Ole Miss prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Charlotte vs. Ole Miss prediction and odds

Using powerful machine learning and data, we have re-simulated the result of Charlotte vs. Ole Miss, forming part of our college football predictions coverage.

Our independent predictive model currently gives Mississippi a 99.5% chance of beating Charlotte. Our predicted final score has Mississippi winning 51-7. According to our model, Charlotte (+45.5) has a 57.6% chance of covering the spread, while the over/under total of 59.5 points has a 52.1% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Charlotte +45.5 (-115) / Ole Miss -45.5 (+100)
• Moneyline: Charlotte , Ole Miss

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Under @ -110 via Bet365

According to our best college football bets, the top play to make on this game is Charlotte +45.5.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Ole Miss and Charlotte at Vaught-Hemingway Stadium is scheduled to begin at 7:45 PM ET.

• Who: Charlotte vs. Mississippi
• Date: Saturday, September 12, 2026
• Time: 7:45 PM ET/4:45PM PT
• Venue: Vaught-Hemingway Stadium

College football Week 2 promos

Make the most of Dimers' Charlotte vs. Mississippi predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Mississippi, with a 99.5% win probability, will likely beat Charlotte in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.