Giants vs. Rams prediction favors Rams to win ‘MNF’ Week 2 [2026]

Since our Giants-Rams predictions earlier in the week, we have re-simulated the result of Monday's NFL game between the Giants and Rams, forming part of our NFL predictions coverage.

Our leading predictive model currently gives the Rams a 74.1% chance of defeating the Giants in Week 2 of the NFL season. Our predicted final score has the Rams winning 27-19.

Key factors favoring the Rams:

• Los Angeles Rams Offensive Efficiency
• Los Angeles Rams Power Rankings
• Los Angeles Rams QB Match-up Differential

According to our model, the Rams (-6.5) have a 56.5% chance of covering the spread, while the over/under total of 47.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.

Latest betting odds

We have researched the best NFL odds in America for this game, which are listed here:

• Spread: Giants +6.5 (+113) / Rams -6.5 (-108)
• Moneyline: Giants +285, Rams -277
• Total: Over/Under 47.5 (-104/+100)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Rams -6.5 @ 52¢ via Novig
• Moneyline: Rams @ 73¢ via Novig
• Total: Under 47.5 @ 50¢ via Novig

According to our best NFL bets, the top play to make on this game is Rams -6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Giants vs. Rams TD scorers

Who will score a touchdown in Giants vs. Rams?

According to our list of touchdown scorer predictions for MNF, Kyren Williams is most likely to score an anytime touchdown in Giants vs. Rams.

Our projections give Williams a 57.4% chance of scoring a TD at SoFi Stadium, while the running back is a 12.9% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

New York Giants

• Cam Skattebo (RB): 42.5% probability
• Malik Nabers (WR): 32.7%
• Jaxson Dart (QB): 27.3%
• Isaiah Likely (TE): 25.7%
• Malachi Fields (WR): 17.6%

Los Angeles Rams

• Kyren Williams (RB): 57.4% prob.
• Davante Adams (WR): 44.9%
• Puka Nacua (WR): 39.3%
• Blake Corum (RB): 35.0%
• Colby Parkinson (TE): 22.3%

First touchdown scorer predictions

New York Giants

• Cam Skattebo (RB): 9.3% prob.
• Malik Nabers (WR): 6.7%
• Jaxson Dart (QB): 5.4%
• Isaiah Likely (TE): 5.0%
• Malachi Fields (WR): 3.3%

Los Angeles Rams

• Kyren Williams (RB): 12.9% prob.
• Davante Adams (WR): 9.0%
• Puka Nacua (WR): 7.6%
• Blake Corum (RB): 6.5%
• Colby Parkinson (TE): 3.8%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Giants and Rams. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.

Quarterbacks

Of the starting quarterbacks, the Giants' Jaxson Dart is projected for 217 passing yards. The Rams' Matthew Stafford is expected to throw for 255 yards.

Giants rushing

• Cam Skattebo: 58 yds
• Jaxson Dart: 36 yds
• Devin Singletary: 18 yds

Rams rushing

• Kyren Williams: 68 yds
• Blake Corum: 53 yds
• Puka Nacua: 2 yds

Giants receiving

• Malik Nabers: 70 yds
• Isaiah Likely: 47 yds
• Malachi Fields: 32 yds
• Darnell Mooney: 21 yds
• Cam Skattebo: 15 yds

Rams receiving

• Puka Nacua: 84 yds
• Davante Adams: 67 yds
• Terrance Ferguson: 34 yds
• Colby Parkinson: 32 yds
• Kyren Williams: 19 yds

Game info & kickoff details

The NFL Week 2 matchup between the Rams and Giants at SoFi Stadium is scheduled to start at 8:15 PM ET.

• Who: New York Giants vs. Los Angeles Rams
• Date: Monday, September 21, 2026
• Time: 8:15 PM ET/5:15PM PT
• Venue: SoFi Stadium

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Conclusion

We predict the Rams, with a 74.1% win probability, will likely beat the Giants in Week 2 of the NFL season.

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This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.