Dolphins vs. 49ers prediction favors San Francisco to win in NFL Week 2 [2026]

Since our Dolphins-49ers predictions earlier in the week, we have re-simulated the result of Sunday's NFL game between the Dolphins and 49ers, forming part of our NFL predictions coverage.

Our leading predictive model currently gives the 49ers an 86.5% chance of beating the Dolphins in Week 2 of the NFL season. Our predicted final score has the 49ers winning 28-15.

Key factors favoring the 49ers:

• San Francisco 49ers Offensive Efficiency
• San Francisco 49ers Power Rankings
• San Francisco 49ers QB Change / Form

According to our model, the 49ers (-12.5) have a 51.3% chance of covering the spread, while the over/under total of 44.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Dolphins +12.5 (-104) / 49ers -12.5 (+100)
• Moneyline: Dolphins +809, 49ers -869
• Total: Over/Under 44.5 (-108/+104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: 49ers -12.5 @ 50¢ via Polymarket
• Moneyline: Dolphins @ 11¢ via Novig
• Total: Under 44.5 @ 49¢ via Novig

According to our NFL best bets, the top play to make on this game is Dolphins to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Dolphins vs. 49ers TD scorers

Who will score a touchdown in Dolphins vs. 49ers?

According to our list of touchdown scorer predictions for Week 2, Christian McCaffrey is most likely to score an anytime TD in Dolphins vs. 49ers.

Our projections give McCaffrey a 61.4% chance of scoring a TD at Levi's Stadium, while the running back is a 17.2% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Miami Dolphins

• De'Von Achane (RB): 43.3% probability
• Malik Willis (QB): 25.4%
• Caleb Douglas (WR): 20.1%
• Malik Washington (WR): 19.8%
• Chris Bell (WR): 14.5%

San Francisco 49ers

• Christian McCaffrey (RB): 61.4% prob.
• Mike Evans (WR): 38.9%
• George Kittle (TE): 31.8%
• Deebo Samuel (WR): 28.7%
• Kaelon Black (RB): 26.7%

First touchdown scorer predictions

Miami Dolphins

• De'Von Achane (RB): 9.8% prob.
• Malik Willis (QB): 5.1%
• Caleb Douglas (WR): 3.9%
• Malik Washington (WR): 3.8%
• Chris Bell (WR): 2.7%

San Francisco 49ers

• Christian McCaffrey (RB): 17.2% prob.
• Mike Evans (WR): 8.9%
• George Kittle (TE): 6.9%
• Deebo Samuel (WR): 6.1%
• Kaelon Black (RB): 5.6%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Dolphins and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.

Quarterbacks

Of the starting quarterbacks, the Dolphins' Malik Willis is projected for 193 passing yards. The 49ers' Brock Purdy is expected to throw for 232 yards.

Dolphins rushing

• De'Von Achane: 64 yds
• Malik Willis: 44 yds
• Jaylen Wright: 10 yds

49ers rushing

• Christian McCaffrey: 64 yds
• Kaelon Black: 41 yds
• Brock Purdy: 16 yds

Dolphins receiving

• Caleb Douglas: 43 yds
• Malik Washington: 39 yds
• De'Von Achane: 30 yds
• Chris Bell: 26 yds
• Greg Dulcich: 26 yds

49ers receiving

• Mike Evans: 55 yds
• George Kittle: 42 yds
• Christian McCaffrey: 40 yds
• Deebo Samuel: 40 yds
• Demarcus Robinson: 32 yds

Game info & kickoff details

The NFL Week 2 game between the 49ers and Dolphins at Levi's Stadium is scheduled to start at 4:25 PM ET.

• Who: Miami Dolphins vs. San Francisco 49ers
• Date: Sunday, September 20, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: Levi's Stadium

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Conclusion

We predict the 49ers, with an 86.5% win probability, will likely beat the Dolphins in Week 2 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.