Jacksonville Jaguars vs. Denver Broncos: Experts release early Week 2 predictions [2026]

The Jacksonville Jaguars and Denver Broncos will meet in Week 2 of the NFL season at Empower Field at Mile High on Sunday, September 20, 2026, starting at 4:05 PM ET.

Early simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this AFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Jaguars vs. Broncos predictions page.

Jacksonville vs. Denver early predictions

Leveraging trusted machine learning and analysis, we have simulated the Jaguars vs. Broncos game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Jaguars 42.6%, Broncos 57.4%
• Predicted final score: Jaguars 21-23 Broncos
• Spread: Jaguars (+2.5) 51.9%, Broncos (-2.5) 48.1%
• Total points (43.5): Over 54.9%, Under 45.1%

As of September 14, 2026, these Jaguars-Broncos numbers and predictions reflect the latest data and insights available.

Jaguars vs. Broncos Week 2 details

Sunday's action between the Broncos and Jaguars at Empower Field at Mile High is scheduled for September 20, 2026.

• Who: Jacksonville Jaguars vs. Denver Broncos
• Date: Sunday, September 20, 2026
• Time: 4:05 PM ET/1:05PM PT
• Venue: Empower Field at Mile High

Jaguars vs. Broncos opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Jaguars +2.5 (-102), Broncos -2.5 (-108)
• Moneyline: Jaguars +133, Broncos -133
• Total: Over/Under 43.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 2 promo

Using our full NFL Week 1 promo code guide, you can make the most of Dimers' Jaguars vs. Broncos predictions with the below DraftKings Sportsbook offer:

Conclusion

We predict the Broncos, with a 57.4% win probability, will likely beat the Jaguars in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Broncos matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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