St. Louis Cardinals vs. Houston Astros Prediction, Odds, MLB Picks [6/5/2024]

St. Louis Cardinals vs. Houston Astros Prediction, Odds, MLB Picks [6/5/2024]

MLB action continues on Wednesday at 2:10PM ET as the St. Louis Cardinals square off with the Houston Astros at Minute Maid Park.

Ronel Blanco (5-1, 2.44 ERA) will start for the Astros, pitting him against Miles Mikolas (3-6, 5.54 ERA) for the Cardinals.'s full preview of Wednesday's Cardinals vs. Astros matchup includes our prediction, picks and the latest betting odds.

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Cardinals vs. Astros Prediction: Who Will Win, Cover the Run Line

We have used innovative machine learning and statistics to simulate the outcome of Wednesday's MLB game between the Cardinals and Astros 10,000 times, in line with our coverage of MLB picks.

Our proven predictive analytics model currently gives the Astros a 57% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Cardinals vs. Astros Odds [6/5/2024]

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Cardinals Astros
Run Line +1.5 (-155) -1.5 (+136)
Moneyline +130 -154
Total o8.5 (-102) u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Astros Picks

At Dimers, our predictions, paired with the current odds, reveal the top betting picks to make on every game, including Cardinals vs. Astros. Our best MLB bets are based on expert modeling and analysis, as you can see.

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Cardinals vs. Astros Game Information

Wednesday's MLB matchup between the Astros and Cardinals at Minute Maid Park is scheduled to commence at 2:10PM ET.


Our full coverage of the Cardinals vs. Astros includes pregame predictions, betting picks and live win probabilities.

Calling Our Shot: Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.


We predict the Astros, with a 57% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua has a deep-rooted passion for sports and has been actively involved in sports betting for many years. Specializing in the MLB, NHL, NBA, MLS, and NFL, Jason delivers engaging game previews across these leagues. His expertise is particularly evident in his best bets for MLB, NHL, and college basketball. Additionally, Jason contributes valuable MLB and NFL props, as well as NBA first basket plays. 

Since joining Dimers in 2020 as the Head of Social and Community, Jason has also made significant contributions to the editorial department, offering daily articles that are not only well-researched but also deeply insightful. His strategic approach and collaboration with DimersBOT ensure his betting advice is top-notch.

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