Cardinals vs. Reds prediction: Why Cincinnati is favored to win Sunday's MLB matchup [5/24/2026]

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Written by Dave Garofolo

Get St. Louis Cardinals vs Cincinnati Reds predictions for MLB Sunday.

St. Louis Cardinals-Cincinnati Reds Predictions and Game Preview.
St. Louis Cardinals vs. Cincinnati Reds MLB prediction for Sunday, May 24, 2026.

The Cincinnati Reds will face the St. Louis Cardinals, in what is expected to be a close MLB game, at Great American Ball Park on Sunday, commencing at 1:40 PM ET.

The Reds will send Brady Singer (2-4, 6.26 ERA) to the mound, while the Cardinals are going with Matthew Liberatore (2-2, 4.70 ERA).

Based on updated simulation results, Dimers' proven MLB model gives the Reds a slight edge with a 54% win probability over the Cardinals.

This article offers further insights into Sunday's Cardinals vs. Reds matchup, including best bets and picks.

Cardinals vs. Reds prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Sunday's MLB matchup between the Cardinals and Reds, forming part of our MLB predictions coverage.

Our famous predictive model gives the Reds a 54% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 9.5 runs has an equal 50-50 chance of hitting.

 

Cardinals vs. Reds odds [5/24/2026]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Cardinals Reds
Run Line +1.5 (-192) -1.5 (+155)
Moneyline +102 -120
Total o9.5 (-110) u9.5 (+100)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Reds picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Reds -1.5 +155
Moneyline Reds -120
Total Under 9.5 +100

According to our MLB best bets, the top play to make on this game is Reds -1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Cardinals vs. Reds game-day updates and essential details

Sunday's MLB matchup between the Reds and Cardinals at Great American Ball Park is scheduled to begin at 1:40 PM ET.

Conclusion

We predict the Reds, with a 54% win probability, will likely beat the Cardinals in Sunday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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