South Florida vs. Louisville CFB Prediction and Odds - Sep 24, 2022

Louisville and South Florida clash in College Football action at Cardinal Stadium on Saturday, starting at 12:00PM ET.

Dimers' free betting picks for South Florida vs. Louisville, as well as game predictions and best odds, are featured in this article.

This South Florida vs. Louisville betting analysis is brought to you by DraftKings Sportsbook, which has a tasty Bet $5, Win $200 promo for new users.


Who will win South Florida vs. Louisville?

Based on cutting-edge computer power and data, has simulated South Florida vs. Louisville 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Louisville a 79% chance of defeating South Florida.

More: Free Betting Guide for South Florida vs. Louisville

South Florida vs. Louisville Game Odds

  • Spread: Louisville -16.5 (-110), South Florida +16.5 (-110)
  • Moneyline: Louisville -575, South Florida +450
  • Total: Over/Under 65.5 (-115/-105)

Point Spread, Moneyline and Over/Under

Louisville is the -16.5 favorite against South Florida, with -110 at FanDuel Sportsbook the best odds currently available.

For the underdog South Florida (+16.5) to cover the spread, FanDuel Sportsbook also has the best odds currently on offer at -110.

PointsBet currently has the best moneyline odds for Louisville at -575. That means you can risk $575 to win $100, for a total payout of $675, if it gets the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for South Florida at +450, where you can bet $100 to profit $450, earning a total payout of $550, if it wins.

The Over/Under for total points scored is set at 65.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -115, as well as the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best College Football odds and lines.

According to DimersBOT, South Florida (+16.5) is a 53% chance of covering the spread, while the 65.5-point Over/Under is a 54% chance of going Under.

More: Track Your Bets via Dimers' Bet Center

Best Bets for South Florida vs. Louisville


Our best bets are based on detailed simulations and wagering intelligence to help you make more informed investments with the legal sportsbooks in the USA.

While Louisville is more likely to win the game, according to DimersBOT, taking South Florida moneyline is the best option due to the 3.2% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on is pivotal to being profitable in the long run.

South Florida vs. Louisville Prediction's predicted final score for South Florida vs. Louisville at Cardinal Stadium this Saturday has Louisville winning 38-24.

Click or tap on See Matchup for more.


Dimers has full coverage of this week's South Florida-Louisville matchup, including pregame predictions, computer picks, and live scores.

Remember, DimersBOT updates often, so keep an eye on this article for any changes to our betting insights ahead of South Florida vs. Louisville on Saturday September 24, 2022.


South Florida vs. Louisville 2022 CFB Game Info

Saturday's matchup between Louisville and South Florida in College Football at Cardinal Stadium is scheduled to commence at 12:00PM ET.

  • Who: South Florida vs. Louisville
  • Date: Saturday September 24, 2022
  • Time: 12:00PM ET / 9:00AM PT
  • Venue: Cardinal Stadium

Ready to join an online sportsbook and start betting on College Football? Check out the best sports betting sign-up offers in your state.

Want more CFB analysis like this?

To get more NCAA Football betting previews like you've just read for South Florida vs. Louisville, all you've gotta do is visit Dimers' College Football Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can write the best CFB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

Related Articles
More Articles