San Francisco 49ers vs. Cleveland Browns: Experts release early Week 13 preview [2025]

The San Francisco 49ers and Cleveland Browns will meet in Week 13 of the NFL season at Huntington Bank Field on Sunday, November 30, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this cross-conference battle.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Browns predictions page.

San Francisco vs. Cleveland early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Browns game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 74%, Browns 26%
• Predicted final score: 49ers 23-17 Browns
• Spread: 49ers (-6) 54%, Browns (+6) 46%
• Total points (39.5): Over 57%, Under 43%

As of November 24, 2025, these 49ers-Browns calculations and predictions reflect the latest data and insights available.

Niners vs. Browns Week 13 details

The NFL Week 13 matchup between the Browns and 49ers at Huntington Bank Field is scheduled for November 30, 2025.

• Who: San Francisco 49ers vs. Cleveland Browns
• Date: Sunday, November 30, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Huntington Bank Field

Niners vs. Browns opening odds

We've researched the best betting odds across America for this Week 13 game, which are listed here:

• Spread: 49ers -6 (-108), Browns +6 (-110)
• Moneyline: 49ers -265, Browns +235
• Total: Over/Under 39.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the 49ers, with a 74% win probability, will likely beat the Browns in Week 13 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Browns game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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