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NFL Week 1 2021: Picks, Predictions and Odds

Week 1 of the 2021 NFL Football season begins on Thursday September 9, with the Bucs and Cowboys featuring in Thursday Night Football at 8:20PM ET.

Once the Bucs vs. Cowboys is done, elsewhere on the NFL Week 1 schedule we have the Steelers vs. Bills on Sunday September 12 at 1PM ET, while the Packers vs. Saints is also on Sunday, at 4:25PM ET.

Other NFL games Week 1 include Eagles vs. Falcons, Jets vs. Panthers, Vikings vs. Bengals, and 49ers vs. Lions – all at 1PM ET on Sunday September 12.

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Also scheduled for Sunday of NFL Week 1 2021 is Seahawks vs. Colts, Cardinals vs. Titans, Chargers vs. Washington, and Browns vs. Chiefs.

Meanwhile, it's the Patriots vs. Dolphins, and the Broncos vs. Giants – with both of those games kicking off at 4:25PM ET on Sunday September 12, 2021.

Then it's a Bears vs. Rams showdown on Sunday Night Football at 8:20PM ET, before Week 1 of the 2021 NFL season concludes with the Ravens vs. Raiders on Monday Night Football at 8:15PM ET.

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NFL Week 1 Predictions 2021

Dimers.com has free picks and parlays for every game of the 2021 National Football League season, including each NFL Week 1 matchup.

As well as dates and times for every 2021 NFL game, Dimers also features NFL Week 1 predictions, odds and spreads.

Dimers’ trusted NFL bets, picks and predictions are published closer to each matchup, so check back here or visit the NFL Bet Hub at Dimers for the latest.

MORE: NFL Week 1 Most Likely Touchdown Scorers

NFL Picks Week 1 2021

Using trusted computer data and analytics, Dimers simulates each game in Week 1 of the 2021 NFL season 10,000 times.

Dimers’ NFL score predictions, including its Week 1 NFL picks, are published here and in the NFL Bet Hub in 2021.

MORE: NFL Week 2 Picks, Predictions and Odds

NFL Odds Week 1 2021

Looking for the best NFL Week 1 odds and legal online sportsbooks to bet with? You’re not alone.

There are many sportsbooks to choose from, such as DraftKings, FanDuel, PointsBet and BetMGM, and finding the books – yes, multiple books – that are right for you is made even harder by all their competitive NFL Week 1 sportsbook sign-up bonuses and promotions.

Then consider your personal preferences and the idea of choosing the best sportsbooks for you to bet with on the NFL can be overwhelming. But have no fear, as Dimers.com is here to help you decide which bookmakers in the United States are best for you today.

MORE: Super Bowl 2022 Odds

Best Sportsbook NFL Offers

  1. DraftKings Sportsbook: Bet $1, Get $200 in Free Bets Instantly After Betting an NFL Game. Click this exclusive link to claim.
  2. PointsBet: Get Boosted +100 Odds for Tom Brady to Throw +1 Yard for the Bucs Against the Cowboys.
  3. FanDuel Sportsbook: Your first NFL bet is risk-free up to $1,000 when you join with Dimers.

MORE: Best 2021 NFL Week 1 Sportsbook Promotions

Full NFL Schedule Week 1 2021

Thursday September 9, 2021


‍Probabilities after 10,000 sims

Sunday September 12, 2021


‍Probabilities after 10,000 sims

Monday September 13, 2021


Probabilities after 10,000 sims


*All 2021 NFL Week 1 times are subject to change.

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