Patriots vs. 49ers Prediction: San Francisco Predicted to Win Following Latest Data Analysis for NFL Week 4 [2024]

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Written by Jason Bevilacqua
New England Patriots-San Francisco 49ers Predictions and Game Preview.
Levi's Stadium sets the stage for the NFL matchup between the New England Patriots and San Francisco 49ers this Sunday.

The San Francisco 49ers and New England Patriots will meet in Week 4 of the NFL season at Levi's Stadium on Sunday, starting at 4:05PM ET.

Based on updated simulation results, Dimers' proven NFL model (see Dimers Pro for full access) projects the 49ers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Patriots-49ers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 83%, while the Patriots have 17%."

Patriots vs. 49ers Game-Day Updates and Essential Details

The NFL Week 4 action between the 49ers and Patriots at Levi's Stadium is scheduled to start at 4:05PM ET.

Dimers.com's comprehensive preview of this week's Patriots vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any 49ers vs. Patriots picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

READER EXCLUSIVE: Sign up with code 20FOOTBALL at checkout right now to receive 20% off your first month of Dimers Pro! This offer won't last forever.

Patriots vs. 49ers Predictions

Using trusted machine learning and statistical analysis, we have simulated the result of Sunday's NFL matchup between the Patriots and 49ers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the 49ers an 83% chance of beating the Patriots in Week 4 of the NFL season. Our predicted final score has the 49ers winning 25-15.

According to our model, the Patriots (+10.5) have a 54% chance of covering the spread, while the 42.5-point over/under has a 54% chance of staying under.

 

Along with our Patriots vs. 49ers predictions, we've also here's what else we've got for today’s action:

Patriots vs. 49ers Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Patriots 49ers
Spread +10.5 (-110) -10.5 (-108)
Moneyline +450 -575
Total o42.5 (-105) u42.5 (-112)

All odds are correct at the time of publication and are subject to change.

Patriots vs. 49ers Picks

Our model's strongest edge in today's Patriots vs. 49ers matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best NFL picks for every game throughout the season.

Full access to our picks, including this one, is available via Dimers Pro.

Patriots vs. 49ers TD Scorers

Who will score the first touchdown in Patriots vs. 49ers?

According to our model, San Francisco's Jordan Mason is most likely to score the first touchdown in Patriots vs. 49ers.

Our projections give Mason a 14.4% chance of scoring the first TD at Levi's Stadium, while the 49ers RB is a 53.6% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

New England Patriots

Player First TD Probability
Rhamondre Stevenson 9.9%
Antonio Gibson 5.0%
Hunter Henry 4.6%

San Francisco 49ers

Player First TD Probability
Jordan Mason 14.4%
Deebo Samuel 10.2%
Brandon Aiyuk 9.2%

Anytime Touchdown Scorer Predictions

New England Patriots

Player Anytime TD Probability
Rhamondre Stevenson 40.4%
Antonio Gibson 22.6%
Hunter Henry 20.9%

San Francisco 49ers

Player Anytime TD Probability
Jordan Mason 53.6%
Deebo Samuel 40.9%
Brandon Aiyuk 38.4%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 4 touchdown scorer predictions

Patriots vs 49ers Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Patriots and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Patriots-49ers page now to access every player prop projection.

Patriots vs. 49ers Quarterbacks

Of the starting quarterbacks, the Patriots' Jacoby Brissett is projected to throw for fewer yards than the 49ers' Brock Purdy.

Patriots Rushing

Rhamondre Stevenson, Antonio Gibson and Jacoby Brissett are projected to be the leading rushers for the Patriots.

Player Position
Rhamondre Stevenson RB
Antonio Gibson RB
Jacoby Brissett QB

49ers Rushing

Jordan Mason, Isaac Guerendo and Deebo Samuel are expected to lead the 49ers in rushing yards.

Player Position
Jordan Mason RB
Isaac Guerendo RB
Deebo Samuel WR

Patriots Receiving

DeMario Douglas, Hunter Henry, Ja'Lynn Polk, K.J. Osborn and Rhamondre Stevenson are projected to top the receiving yards for the Patriots.

Player Position
DeMario Douglas WR
Hunter Henry TE
Ja'Lynn Polk WR
K.J. Osborn WR
Rhamondre Stevenson RB

49ers Receiving

Brandon Aiyuk, Deebo Samuel, George Kittle, Jauan Jennings and Jordan Mason are projected to lead the 49ers in receiving yards.

Player Position
Brandon Aiyuk WR
Deebo Samuel WR
George Kittle TE
Jauan Jennings WR
Jordan Mason RB

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Conclusion

We predict the 49ers, with an 83% win probability, will likely beat the Patriots in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Patriots vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Keep up with the latest NFL betting news and our data-driven NFL best bets and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the most up-to-date projections for the Super Bowl, AFC, NFC and each division.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS and NFL, delivers game previews, best bets and props and has contributed insightful articles at Dimers since 2020 as Head of Social and Community.

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