Nationals vs. Padres Prediction and Odds - Aug 21, 2022

The San Diego Padres and Washington Nationals lock horns in MLB at PETCO Park on Sunday, starting at 4:10PM ET.

Sean Manaea (6-6, 4.83 ERA) will be on the bump for the Padres, pitting him against Patrick Corbin (4-16, 6.96 ERA) for the Nationals.

Dimers' top betting picks for Nationals vs. Padres, as well as game predictions and best odds, are featured below.

Who will win Nationals vs. Padres?

Based on state-of-the-art computer power and data, Dimers.com has simulated Sunday's Nationals-Padres MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Padres a 69% chance of defeating the Nationals.

More: Nationals vs. Padres Simulated 10K Times

Nationals vs. Padres Game Odds

• Run Line: Padres -1.5 (-135), Nationals +1.5 (+118)
• Moneyline: Padres -275, Nationals +240
• Total: Over/Under 8.5 (-105/-112)

Run Line, Moneyline and Over/Under

The Padres are -1.5 favorites versus the Nationals, with -135 at DraftKings Sportsbook the best odds currently available.

For the underdog Nationals (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +118.

BetMGM currently has the best moneyline odds for the Padres at -275. That means you can risk $275 to win $100, for a total payout of $375, if they get the W.

Meanwhile, PointsBet currently has the best moneyline odds for the Nationals at +240, where you can bet $100 to profit $240, earning a total payout of $340, if they win.

The Over/Under for total runs scored is set at 8.5 with PointsBet, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -112.

As always, check out all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the bookies have got it right and both the Nationals and Padres are a 50% chance of covering the run line, while the Over/Under total of 8.5 runs is a 52% chance of going Under.

More: Best Bets for Every MLB Matchup

Best Bets for Nationals vs. Padres

• Run Line: Nationals +1.5 @ +118 via FanDuel Sportsbook (50% probability) 🔥
• Moneyline: Nationals @ +240 via PointsBet (1.8% edge)
• Total: Under 8.5 @ -112 via FanDuel Sportsbook (52% probability)

Every time you see a 🔥, that means you've found one of our best bets today across all sports.

Our best bets are based on complex modeling and gambling intelligence to bring you the best possible plays 24/7.

While the Padres are more likely to win the game, according to DimersBOT, taking the Nationals moneyline is the best option due to the 1.8% edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen here at Dimers.com is one of the keys to being profitable in the long run.

Nationals vs. Padres Prediction

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Washington vs. San Diego, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Sunday's Nationals-Padres matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this article for any changes to our betting analysis before Nationals vs. Padres on Sunday August 21, 2022.

Best Betting Offer for Nationals vs. Padres

Are you looking to bet on Washington vs. San Diego? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on Sunday's Nationals-Padres matchup.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

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Note: When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial relationship with (such as a sportsbook), we may get a referral fee.

Nationals vs. Padres 2022 Game Info

Sunday's game between the Padres and Nationals at PETCO Park is scheduled to start at 4:10PM ET.

• Who: San Diego Padres vs. Washington Nationals
• Date: Sunday August 21, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: PETCO Park

Want to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers in each and every legal betting state.

What other MLB games are on today?

Now you've got the 411 on Nationals vs. Padres, get the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, plus our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.