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Louisville vs. Southern California Prediction, Odds, College Football Picks - Week 18 [2023]

Louisville vs. Southern California Prediction, Odds, College Football Picks - Week 18 [2023]

Southern California takes on the favored Louisville in the 2023 Holiday Bowl at Petco Park on Wednesday, commencing at 8:00PM ET.

Dimers.com's full betting preview for Wednesday's Louisville vs. Southern California matchup includes the latest betting odds, as well as our predictions and picks for the game.

Holiday Bowl Prediction: Who Will Win, Cover the Spread

We have used innovative machine learning and statistical analysis to simulate the outcome of the 2023 Holiday Bowl 10,000 times, in keeping with our coverage of College Football predictions.

Our famous predictive analytics model currently gives Louisville a 57% chance of defeating Southern California, and our predicted final score has Louisville winning 30-27.

According to our model, Southern California (+4.5) has a 59% chance of covering the spread, while the Over/Under total of 57.5 points has a 52% chance of going under.

This Louisville vs. Southern California betting preview is brought to you by Bet365, which has a tasty Bet $5, Get $150 in Bonus Bets offer for new customers.

Holiday Bowl Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Louisville Southern California
Spread -4.5 (-110) +4.5 (-110)
Moneyline -300 +160
Total o57.5 (-115) u57.5 (-105)
  • Southern California is the +4.5 underdog versus Louisville, with -110 at DraftKings Sportsbook the best odds currently available.
  • For the favored Louisville (-4.5) to cover the spread, DraftKings also has the best odds currently on offer at -110.
  • DraftKings currently has the best moneyline odds for Southern California at +160. That means you can throw down $100 to profit $160, earning a total payout of $260, if it wins.
  • On the other hand, BetMGM Sportsbook currently has the best moneyline odds for Louisville at -300, where you can risk $300 to win $100 for a total payout of $400 if it comes out on top.
  • The Over/Under sits at 57.5 with BetMGM, which currently has the best odds for the Over at -115, as well as the best odds for the Under at -105.

All odds are correct at the time of publication and are subject to change.

As always, check out the sportsbooks you have access to in your state for the best College Football odds and lines.

Louisville vs. Southern California Picks

By comparing our predictions to the odds listed above, we have identified the best betting picks for this game:

Bet Type Our Pick Best Odds
Spread Southern California +4.5 -110 🔥
Moneyline Southern California +160 🔥
Total Under 57.5 -105


If you see a 🔥, that means it's one of our best bets of the day across all major pro and college sports.

While Louisville is more likely to win the game, taking Southern California moneyline is the best option due to the 5.0% edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers is one of the keys to being profitable in the long run.

Dimers' College Football best bets are based on world-class modeling and betting intelligence to serve you the best possible plays every week of the season.

Remember, our model updates frequently, so keep an eye on this article for any changes to our betting insights ahead of Louisville vs. Southern California on Wednesday December 27, 2023.

Louisville vs. Southern California Game Information

Wednesday's matchup between Southern California and Louisville in College Football at Petco Park is scheduled to commence at 8:00PM ET.

  • Who: Louisville vs. Southern California
  • Date: Wednesday December 27, 2023
  • Time: 8:00PM ET / 5:00PM PT
  • Venue: Petco Park


Our full betting coverage of Louisville vs. Southern California includes pregame predictions, betting picks, and live updates.

How to Bet on Louisville vs. Southern California

Enjoy Dimers.com and want to keep the site free? Every time you sign up and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for everyone. So, if you like what you see, support us by joining one of our featured sports betting partners below, including DraftKings Sportsbook, where you get $200 in bonus bets for signing up and bettting $5 on Louisville vs. Southern California.


This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on this week's Louisville vs. Southern California game, and automation assists in data collection, analysis, and formatting. Human editing and quality control are performed to ensure the content meets our editorial standards.

Our predictions are made thanks to 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While these Louisville vs. Southern California predictions can help you make informed decisions, it's crucial that you gamble responsibly and manage your finances effectively.

To increase your likelihood to be a responsible gambler, we recommended checking out this full guide to Kentucky sports betting as well as utilizing these .Kentucky sportsbook promos that can get you started off on the right foot.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial relationship with (such as a sportsbook), we may get a referral fee at no additional cost to you.

More on College Football

Stay up-to-date with the latest College Football betting news and our analytics-driven College Football picks and parlays all season long. Plus, our College Football National Championship odds give you the latest projections and the best available odds on the CFP, as well as each of the major conferences and divisions.

Mac Douglass
Senior Sports Betting Editor

Mac brings a well-traveled perspective and a broad knowledge of sports to his role at Dimers. Specializing in previews for the NFL, particularly the NFC South and NFC East, Mac leverages his keen insights to provide detailed game analyses. He also offers best bets and props for MLB and race previews for Formula 1, a sport he has followed passionately alongside professional tennis and the NBA. 

Known for his knack for discovering the best new user promos across major sportsbooks, Mac is dedicated to sharing these finds with the community, enhancing both the novice and veteran bettor's experience. Having lived in New York, San Francisco, Los Angeles, and Melbourne, Australia, Mac's diverse experiences enrich his understanding of both American and international sports landscapes.

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