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Louisville vs. Southern California Prediction, Odds, College Football Picks - Week 18 [2023]

Louisville vs. Southern California Prediction, Odds, College Football Picks - Week 18 [2023]

Southern California and Louisville lock horns in the 2023 Holiday Bowl at Petco Park on Wednesday, with kickoff at 8:00PM ET.

Dimers.com's in-depth betting preview for Wednesday's Louisville vs. Southern California matchup includes the latest betting odds, as well as our predictions and picks for the game.

Holiday Bowl Prediction: Who Will Win, Cover the Spread

We have used innovative machine learning and data analysis to simulate the result of the 2023 Holiday Bowl 10,000 times, in line with our coverage of College Football predictions.

Our leading predictive analytics model gives Louisville a 57% chance of beating Southern California, and our predicted final score has Louisville winning 30-27.

According to our model, Southern California (+4.5) has a 59% chance of covering the spread, while the 57.5-point Over/Under has a 52% chance of going under.

Today's Louisville vs. Southern California betting preview is proudly sponsored by Bet365, which has a great Bet $5, Get $150 in Bonus Bets offer for new customers.

Holiday Bowl Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type Louisville Southern California
Spread -4.5 (-110) +4.5 (-110)
Moneyline -300 +160
Total o57.5 (-115) u57.5 (-105)
  • Southern California is the +4.5 underdog versus Louisville, with -110 at DraftKings Sportsbook the best odds currently available.
  • For the favored Louisville (-4.5) to cover the spread, DraftKings also has the best odds currently on offer at -110.
  • DraftKings currently has the best moneyline odds for Southern California at +160, which means you can bet $100 to profit $160, earning a total payout of $260, if it wins.
  • Elsewhere, BetMGM Sportsbook currently has the best moneyline odds for Louisville at -300, where you can risk $300 to win $100 for a total payout of $400 if it comes out on top.
  • The Over/Under is set at 57.5 with BetMGM, which currently has the best odds for the Over at -115, as well as the best odds for the Under at -105.

All odds are correct at the time of publication and are subject to change.

As always, make sure you check the sports betting sites you can bet with in your state for the best College Football odds and lines.

Louisville vs. Southern California Picks

By comparing our predictions to the odds listed above, we have determined the best betting picks for this game:

Bet Type Our Pick Best Odds
Spread Southern California +4.5 -110 🔥
Moneyline Southern California +160 🔥
Total Under 57.5 -105


Any time you see a 🔥, that means it's one of Dimers' best free picks of the day across any sport.

While Louisville is more likely to win the game, betting on Southern California moneyline is the best option because of the 5.0% edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers is pivotal to achieving long-term profitability as a bettor.

Our best College Football bets are based on detailed modeling and betting expertise to serve you the best possible plays every time.

Don't forget, our model updates often, so keep checking this article for any changes to our betting insights ahead of Louisville vs. Southern California on Wednesday December 27, 2023.

Louisville vs. Southern California Game Information

Wednesday's matchup between Southern California and Louisville in College Football at Petco Park is scheduled to start at 8:00PM ET.

  • Who: Louisville vs. Southern California
  • Date: Wednesday December 27, 2023
  • Time: 8:00PM ET / 5:00PM PT
  • Venue: Petco Park


Our full betting coverage of Louisville vs. Southern California includes pregame predictions, betting picks, and live win probabilities.

How to Bet on Louisville vs. Southern California

Want to join an online sportsbook and start betting on College Football? We've got access to the best available sign-up offers in every legal betting state, including DraftKings Sportsbook, where you get $200 in bonus bets for signing up and bettting $5 on Louisville vs. Southern California.


This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on this week's Louisville vs. Southern California contest, and automation assists in data collection, analysis, and formatting. Human editing and quality control are performed to ensure the content meets our editorial guidelines.

Dimers' picks and predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While these Louisville vs. Southern California predictions can help you make informed decisions, it's vital that you gamble responsibly and manage your finances effectively.

To increase your likelihood to be a responsible gambler, we recommended reading this full guide to Kentucky sports betting as well as utilizing these .Kentucky sportsbook promos that can get you started off on the right foot.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may get a referral fee at no additional cost to you.

More on College Football

Stay well-informed with the most recent College Football betting news and our data-led College Football picks and parlays all season long. Plus, our College Football National Championship odds give you the latest probabilities and the best available odds on the CFP, as well as each of the major conferences and divisions.

Mac Douglass
Senior Sports Betting Editor

Mac brings a well-traveled perspective and a broad knowledge of sports to his role at Dimers. Specializing in previews for the NFL, particularly the NFC South and NFC East, Mac leverages his keen insights to provide detailed game analyses. He also offers best bets and props for MLB and race previews for Formula 1, a sport he has followed passionately alongside professional tennis and the NBA. 

Known for his knack for discovering the best new user promos across major sportsbooks, Mac is dedicated to sharing these finds with the community, enhancing both the novice and veteran bettor's experience. Having lived in New York, San Francisco, Los Angeles, and Melbourne, Australia, Mac's diverse experiences enrich his understanding of both American and international sports landscapes.

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