Houston Texans vs. Indianapolis Colts: Experts release early Week 13 preview [2025]

The Houston Texans and Indianapolis Colts will meet in Week 13 of the NFL season at Lucas Oil Stadium on Sunday, November 30, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Colts as the most likely winner of this AFC South rivalry clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Texans vs. Colts predictions page.

Houston vs. Indianapolis early predictions

Leveraging trusted machine learning and analysis, we have simulated the Texans vs. Colts game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Texans 32%, Colts 68%
• Predicted final score: Texans 20-24 Colts
• Spread: Texans (+4.5) 50%, Colts (-4.5) 50%
• Total points (44.5): Over 55%, Under 45%

As of November 24, 2025, these Texans-Colts figures and predictions reflect the latest data and insights available.

Texans vs. Colts Week 13 details

The NFL Week 13 action between the Colts and Texans at Lucas Oil Stadium is scheduled for November 30, 2025.

• Who: Houston Texans vs. Indianapolis Colts
• Date: Sunday, November 30, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium

Texans vs. Colts opening odds

We've researched the best betting odds across America for this Week 13 game, which are listed here:

• Spread: Texans +4.5 (-110), Colts -4.5 (-105)
• Moneyline: Texans +185, Colts -215
• Total: Over/Under 44.5 (-105/-108)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Colts, with a 68% win probability, will likely beat the Texans in Week 13 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Texans vs. Colts game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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