May 24, 2026
Mets vs. Marlins prediction: Tight battle projected in updated analysis for Sunday's MLB matchup [5/24/2026]
Read Article Astros vs. Cubs prediction: Why Cubs are favored to win Sunday's MLB matchup [5/24/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Houston Astros vs Chicago Cubs predictions for MLB Sunday.
The Chicago Cubs and Houston Astros will lock horns in MLB action at Wrigley Field on Sunday, starting at 2:20 PM ET.
Shota Imanaga (4-4, 3.38 ERA) will be on the bump for the Cubs, pitting him against Peter Lambert (2-4, 3.57 ERA) for the Astros.
Based on the latest simulations, Dimers' proven MLB model predicts the Cubs as the most likely winner of the Astros vs. Cubs game.
This article offers an expanded analysis of Sunday's matchup, including best bets and picks.
Astros vs. Cubs prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Sunday's MLB matchup between the Astros and Cubs, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Cubs a 58% chance of beating the Astros.
According to our model, the Astros (+1.5) have a 60% chance of covering the run line, while the over/under total of 7.5 runs has a 55% chance of going over.
Astros vs. Cubs odds [5/24/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Astros | Cubs |
|---|---|---|
| Run Line | +1.5 (-149) | -1.5 (+128) |
| Moneyline | +150 | -178 |
| Total | o7.5 (+105) | u7.5 (-125) |
All odds are correct at the time of publication and are subject to change.
Astros vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros +1.5 | -149 |
| Moneyline | Astros | +150 |
| Total | Over 7.5 | +105 |
According to our best MLB bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Astros vs. Cubs game-day updates and essential details
Sunday's MLB game between the Cubs and Astros at Wrigley Field is scheduled to commence at 2:20 PM ET.
- Who: Houston Astros vs. Chicago Cubs
- Date: Sunday, May 24, 2026
- Time: 2:20 PM ET/11:20AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 58% win probability, will likely beat the Astros in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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