Guardians vs. White Sox Prediction and Odds - Sep 20, 2022

The Chicago White Sox square off with the Cleveland Guardians in MLB action at Guaranteed Rate Field on Tuesday, starting at 8:10PM ET.

Dylan Cease (14-7, 2.16 ERA) will start on the mound for the White Sox, pitting him against Aaron Civale (2-6, 5.40 ERA) for the Guardians.

Dimers' free betting picks for Guardians vs. White Sox, plus game predictions and best odds, are detailed in this article.

Who will win Guardians vs. White Sox?

Using cutting-edge computer power and data, Dimers.com has simulated Tuesday's Guardians-White Sox MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the White Sox a 61% chance of getting the W against the Guardians.

More: Guardians vs. White Sox Simulated 10K Times

Guardians vs. White Sox Game Odds

• Run Line: White Sox -1.5 (+130), Guardians +1.5 (-137)
• Moneyline: White Sox -169, Guardians +152
• Total: Over/Under 7 (-115/+105)

Run Line, Moneyline and Over/Under

The White Sox are -1.5 favorites against the Guardians, with +130 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -137.

Caesars Sportsbook currently has the best moneyline odds for the White Sox at -169. That means you can risk $169 to win $100, for a total payout of $269, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +152, where you can put down $100 to profit $152, earning a total payout of $252, if they win.

The Over/Under for total runs scored is set at 7 with BetMGM, which currently has the best odds for the Over at -115, while DraftKings Sportsbook currently has the best odds for the Under at +105.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 57% chance of covering the run line, while the 7-run Over/Under is a 60% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Guardians vs. White Sox

• Run Line: Guardians +1.5 @ -137 via FanDuel Sportsbook (57% probability)
• Moneyline: Guardians @ +152 via FanDuel Sportsbook
• Total: Over 7 @ -115 via BetMGM (60% probability) 🔥

When you see a 🔥, that means it's one of Dimers' best bets today across all sports.

Dimers' best bets are based on complex modeling and gambling intelligence to bring you the best possible plays every time.

While the White Sox are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers is pivotal to being a profitable bettor in the long run.

Guardians vs. White Sox Probabilities

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Dimers has full coverage of Tuesday's Guardians-White Sox matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for any changes to our betting analysis before Guardians vs. White Sox on Tuesday September 20, 2022.

Guardians vs. White Sox 2022 Game Info

Tuesday's game between the White Sox and Guardians at Guaranteed Rate Field is scheduled to start at 8:10PM ET.

• Who: Cleveland Guardians vs. Chicago White Sox
• Date: Tuesday September 20, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Guaranteed Rate Field

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