Frances Tiafoe vs. Francisco Comesana prediction, odds, picks for 2026 Australian Open

Frances Tiafoe will square off with Francisco Comesana in the second round of the 2026 Australian Open on Tuesday.

Based on the latest simulation results, Dimers' proven tennis model predicts Frances Tiafoe as the most likely winner of the Tiafoe vs. Comesana match.

This article offers further insights into Tuesday's match, including best bets and picks.

Tiafoe vs. Comesana prediction: Who will win and advance to the round of 32?

Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's Tiafoe-Comesana men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model currently gives Tiafoe a 77% chance of defeating Comesana in the 2026 Australian Open.

Additionally, Tiafoe has a 71% chance of winning the first set. The simulations also show Tiafoe (-4.5) has a 53% chance of covering the games spread, while the under 38.5 games has a 59% chance of hitting**, according to our model.

Frances Tiafoe vs. Francisco Comesana odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

Tiafoe vs. Comesana picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: