Diamondbacks vs. Astros Prediction and Odds - Sep 28, 2022

The Houston Astros and Arizona Diamondbacks meet in MLB at Minute Maid Park on Wednesday, starting at 8:10PM ET.

Justin Verlander (17-4, 1.82 ERA) will start on the mound for the Astros, while the Diamondbacks will counter with Zac Gallen (12-3, 2.46 ERA).

Dimers' top betting picks for Diamondbacks vs. Astros, plus game predictions and betting odds, are featured below.

Who will win Diamondbacks vs. Astros?

Based on high-tech machine learning and data, Dimers.com has simulated Wednesday's Diamondbacks-Astros MLB matchup 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Astros a 60% chance of getting the W against the Diamondbacks.

More: Diamondbacks vs. Astros Simulated 10,000 Times

Diamondbacks vs. Astros Game Odds

• Run Line: Astros -1.5 (+140), Diamondbacks +1.5 (-145)
• Moneyline: Astros -165, Diamondbacks +146
• Total: Over/Under 6 (-115/+100)

Run Line, Moneyline and Over/Under

The Astros are currently -1.5 favorites against the Diamondbacks, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Diamondbacks (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -145.

DraftKings Sportsbook currently has the best moneyline odds for the Astros at -165. That means you can risk $165 to win $100, for a total payout of $265, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Diamondbacks at +146, where you can bet $100 to profit $146, earning a total payout of $246, if they win.

The Over/Under for total runs scored is set at 6 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Diamondbacks (+1.5) are a 60% chance of covering the run line, while the 6-run Over/Under is a 62% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Diamondbacks vs. Astros

• Run Line: Diamondbacks +1.5 @ -145 via BetMGM (60% probability)
• Moneyline: Diamondbacks @ +146 via FanDuel Sportsbook
• Total: Over 6 @ -115 via Caesars Sportsbook (62% probability) 🔥

Any time you see a 🔥, you know it's one of Dimers' best bets today across all major pro and college sports.

Our best bets are based on complex simulations and betting expertise to help you make better decisions with the legal sportsbooks in the United States.

While the Astros are more likely to win the game, according to DimersBOT, taking the Diamondbacks moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers.com is crucial to being a profitable bettor in the long run.

Diamondbacks vs. Astros Prediction

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Dimers has full coverage of Wednesday's Diamondbacks-Astros matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this page for any changes to our betting analysis ahead of Diamondbacks vs. Astros on Wednesday September 28, 2022.

Diamondbacks vs. Astros 2022 Game Info

Wednesday's action between the Astros and Diamondbacks at Minute Maid Park is scheduled to begin at 8:10PM ET.

• Who: Arizona Diamondbacks vs. Houston Astros
• Date: Wednesday September 28, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Minute Maid Park

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