Cubs vs. Pirates Prediction and Odds - Sep 22, 2022

The Pittsburgh Pirates and Chicago Cubs lock horns in MLB at PNC Park on Thursday, starting at 6:35PM ET.

The Pirates will have Mitch Keller (5-11, 4.03 ERA) start, up against Hayden Wesneski (1-1, 2.30 ERA) for the Cubs.

Dimers' free betting picks for Cubs vs. Pirates, plus game predictions and betting odds, are featured below.


Who will win Cubs vs. Pirates?

Using cutting-edge machine learning and data, has simulated Thursday's Cubs-Pirates MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Pirates a 53% chance of defeating the Cubs.

More: Cubs vs. Pirates Simulated 10K Times

Cubs vs. Pirates Current Odds

  • Run Line: Pirates +1.5 (-194), Cubs -1.5 (+170)
  • Moneyline: Pirates -116, Cubs +100
  • Total: Over/Under 7.5 (-105/-106)

Run Line, Moneyline and Over/Under

The Pirates are currently +1.5 underdogs against the Cubs, with -194 at FanDuel Sportsbook the best odds currently available.

For the favored Cubs (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +170.

FanDuel Sportsbook currently has the best moneyline odds for the Pirates at -116. That means you can risk $116 to win $100, for a total payout of $216, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Cubs at +100, where you can risk $100 to win $100, for a total payout of $200, if they come out on top.

The Over/Under for total runs scored sits at 7.5 with BetMGM, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -106.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 67% chance of covering the run line, while the Over/Under total of 7.5 runs is a 52% chance of going Over.

More: Best Prop Bets Today

Best Bets for Cubs vs. Pirates


Our best bets are based on world-class modeling and gambling expertise to help you make more informed decisions with your state's legal sportsbooks.

Cubs vs. Pirates Betting Guide

Click or tap on See Matchup to reveal more.


Dimers has full betting coverage of Thursday's Cubs-Pirates matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for the latest betting insights ahead of Cubs vs. Pirates on Thursday September 22, 2022.


Cubs vs. Pirates 2022 Game Info

Thursday's game between the Pirates and Cubs at PNC Park is scheduled to begin at 6:35PM ET.

  • Who: Chicago Cubs vs. Pittsburgh Pirates
  • Date: Thursday September 22, 2022
  • Time: 6:35PM ET / 3:35PM PT
  • Venue: PNC Park

Ready to join an online sportsbook and start betting on MLB? We've reviewed the best available welcome offers for each legal betting state.

What other MLB games are on today?

Now you've got the 411 on Cubs vs. Pirates, check out the latest betting predictions for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.

Related Articles
More Articles