Cleveland Guardians vs. Houston Astros Prediction, Odds, MLB Picks [5/1/2024]

Cleveland Guardians vs. Houston Astros Prediction, Odds, MLB Picks [5/1/2024]

MLB action continues on Wednesday at 8:10PM ET as the Cleveland Guardians take on the Houston Astros at Minute Maid Park.

Justin Verlander (1-0, 1.74 ERA) will be on the bump for the Astros, up against Triston McKenzie (2-2, 4.91 ERA) for the Guardians.'s comprehensive preview of Wednesday's Guardians vs. Astros matchup includes our prediction, picks and the latest betting odds.

JOIN NOW: Dimers Pro unlocks +EV bets daily. We give you the tools and information to succeed with hundreds of data-driven bets across thousands of games. Join Dimers Pro now for less than $1 a day!

Guardians vs. Astros Prediction: Who Will Win, Cover the Run Line

We have used advanced machine learning and statistics to simulate the outcome of Wednesday's MLB game between the Guardians and Astros 10,000 times, in line with our coverage of MLB picks.

Our proven predictive analytics model currently gives the Astros a 61% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 57% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Guardians vs. Astros Odds [5/1/2024]

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Guardians Astros
Run Line +1.5 (-130) -1.5 (+112)
Moneyline +154 -184
Total o8.5 (-112) u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Guardians vs. Astros Picks

At Dimers, our predictions, paired with the current odds, reveal the top betting picks for every game, including Guardians vs. Astros. Our MLB best bets are based on expert modeling and analysis, as you can see.

Dimers Pro gives sports bettors an edge. Through Dimers Pro, we give you the tools and information to succeed with hundreds of data-driven bets across thousands of games. Join now to find any potential picks for this matchup.


Guardians vs. Astros Game Information

Wednesday's MLB matchup between the Astros and Guardians at Minute Maid Park is scheduled to begin at 8:10PM ET.


Our full coverage of the Guardians vs. Astros includes pregame predictions, betting picks and live win probabilities.

Calling Our Shot: Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.


We predict the Astros, with a 61% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on MLB

Stay well-informed with the most recent MLB betting news and our analytics-driven MLB picks and parlays all season long. Plus, our World Series odds give you the most up-to-date projections and the best available odds on the World Series, American League, National League, and each division.

Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua has a deep-rooted passion for sports and has been actively involved in sports betting for many years. Specializing in the MLB, NHL, NBA, MLS, and NFL, Jason delivers engaging game previews across these leagues. His expertise is particularly evident in his best bets for MLB, NHL, and college basketball. Additionally, Jason contributes valuable MLB and NFL props, as well as NBA first basket plays. 

Since joining Dimers in 2020 as the Head of Social and Community, Jason has also made significant contributions to the editorial department, offering daily articles that are not only well-researched but also deeply insightful. His strategic approach and collaboration with DimersBOT ensure his betting advice is top-notch.

On the socials
More from Dimers
About Dimers
icon 22,000+
Events covered per year
icon 8,000,000+
Our partners