Clemson vs. Louisville CFB Predictions and Odds - Nov 6, 2021

Louisville hosts Clemson in College Football Week 10 action at Cardinal Stadium on Saturday, beginning at 7:30 PM EDT.

Dimers' best betting picks for Clemson vs. Louisville, as well as game predictions and best odds, are featured below.

Who will win Clemson vs. Louisville?

Using trusted computer power and data, Dimers.com has simulated Saturday's Clemson-Louisville game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives Clemson a 55% chance of winning against Louisville.

MORE: Clemson vs. Louisville simulated 10,000 times

Clemson vs. Louisville Point Spread, Moneyline and Over/Under

Louisville is the +3.5 underdog at home to Clemson, with -110 at Caesars Sportsbook the best odds available.

For the favored Clemson (-3.5) to cover the spread, FanDuel Sportsbook has the best odds on the market at -106.

DraftKings Sportsbook has the best moneyline odds for Louisville at +155. That means you can bet $100 to profit $155, earning a total payout of $255, if it wins.

Meanwhile, Caesars Sportsbook has the best moneyline odds for Clemson at -179, where you can risk $179 to win $100, for a total payout of $279, if it comes out on top.

The Over/Under for total points scored sits at 46.5 with PointsBet, which has the best odds for the Over at -105, while Caesars Sportsbook has the best odds for the Under at -115.

As always, make sure you check all the legal sportbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Louisville (+3.5) is a 58% chance of covering the spread, while the 46.5-point Over/Under is a 55% chance of going Under.

Best Bets for Clemson vs. Louisville

• Spread: Louisville +3.5 at -110 with Caesars Sportsbook (58% probability) 🔥
• Moneyline: Louisville Win at +155 with DraftKings Sportsbook (5.6% edge) 🔥
• Over/Under: Under 46.5 at -115 with Caesars Sportsbook (55% probability)

When you see a 🔥, that means you've found one of our best bets of the day across all sports.

While Clemson is more likely to win the game, according to DimersBOT, betting on Louisville moneyline is the best option because of the 5.6% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published on Dimers.com is pivotal to being a profitable bettor in the long run.

MORE: Best bets today for all major pro and college sports

Clemson vs. Louisville Predicted Score

Dimers.com's predicted score for Clemson vs. Louisville at Cardinal Stadium this Saturday has Clemson winning 24-23.

Dimers has full betting coverage of this week's Clemson-Louisville matchup, including pre-game predictions, top betting picks, live scores, and play-by-play commentary.

Don't forget, DimersBOT updates frequently, so keep checking this page for the latest before Clemson vs. Louisville on Saturday November 6, 2021.

Clemson vs. Louisville 2021 CFB Game Info

When does Louisville play Clemson?

• Date: Saturday November 6, 2021
• Time: 7:30 PM EDT / 4:30 PM PDT
• Venue: Cardinal Stadium

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