Cardinals vs. Padres Prediction and Odds - Sep 21, 2022

The San Diego Padres square off with the St. Louis Cardinals in MLB action at PETCO Park on Wednesday, commencing at 9:40PM ET.

Blake Snell (7-9, 3.84 ERA) will be on the bump for the Padres, pitting him against Miles Mikolas (11-12, 3.46 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Padres, plus game predictions and betting odds, are detailed below.


Who will win Cardinals vs. Padres?

Based on trusted machine learning and data, has simulated Wednesday's Cardinals-Padres MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Padres a 55% chance of beating the Cardinals.

More: Cardinals vs. Padres Simulated 10K Times

Cardinals vs. Padres Game Odds

  • Run Line: Padres -1.5 (+160), Cardinals +1.5 (-178)
  • Moneyline: Padres -135, Cardinals +120
  • Total: Over/Under 7.5 (-105/-110)

Run Line, Moneyline and Over/Under

The Padres are -1.5 favorites against the Cardinals, with +160 at DraftKings Sportsbook the best odds currently available.

For the underdog Cardinals (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -178.

BetMGM currently has the best moneyline odds for the Padres at -135, which means you can risk $135 to win $100, for a total payout of $235, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at +120, where you can bet $100 to profit $120, earning a total payout of $220, if they win.

The Over/Under sits at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Cardinals (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 7.5 runs is a 54% chance of going Over.

More: Free Prop Picks

Best Bets for Cardinals vs. Padres


Dimers' best bets are based on world-class modeling and betting intelligence to serve you the best possible plays every time.

Even though the Cardinals are more likely to cover the run line, our best bet of Padres -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

And while the Padres are more likely to win the game, according to DimersBOT, betting on the Cardinals moneyline is the best option due to the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is crucial to being a profitable sports bettor in the long run.

Cardinals vs. Padres Prediction

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Dimers has full coverage of Wednesday's Cardinals-Padres matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for the latest betting analysis before Cardinals vs. Padres on Wednesday September 21, 2022.


Cardinals vs. Padres 2022 Game Info

Wednesday's action between the Padres and Cardinals at PETCO Park is scheduled to start at 9:40PM ET.

  • Who: St. Louis Cardinals vs. San Diego Padres
  • Date: Wednesday September 21, 2022
  • Time: 9:40PM ET / 6:40PM PT
  • Venue: PETCO Park

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