Buffalo Bills vs. Pittsburgh Steelers: Experts release early Week 13 preview [2025]

The Buffalo Bills and Pittsburgh Steelers will meet in Week 13 of the NFL season at Acrisure Stadium on Sunday, November 30, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this AFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Steelers predictions page.

Buffalo vs. Pittsburgh early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Steelers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 63%, Steelers 37%
• Predicted final score: Bills 25-22 Steelers
• Spread: Bills (-4.5) 46%, Steelers (+4.5) 54%
• Total points (46.5): Over 50%, Under 50%

As of November 24, 2025, these Bills-Steelers numbers and predictions reflect the latest data and insights available.

Bills vs. Steelers Week 13 details

The NFL Week 13 game between the Steelers and Bills at Acrisure Stadium is scheduled for November 30, 2025.

• Who: Buffalo Bills vs. Pittsburgh Steelers
• Date: Sunday, November 30, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Acrisure Stadium

Bills vs. Steelers opening odds

We've researched the best betting odds across America for this Week 13 game, which are listed here:

• Spread: Bills -4.5 (-115), Steelers +4.5 (-105)
• Moneyline: Bills -218, Steelers +180
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 63% win probability, will likely beat the Steelers in Week 13 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Steelers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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