Brewers vs. Reds Prediction and Odds - Sep 23, 2022

The Cincinnati Reds and Milwaukee Brewers are scheduled to meet in MLB at Great American Ball Park on Friday, starting at 6:40PM ET.

Luis Cessa (4-3, 4.85 ERA) will be on the bump for the Reds, up against Eric Lauer (10-7, 3.91 ERA) for the Brewers.

Dimers' free betting picks for Brewers vs. Reds, plus game predictions and betting odds, are featured in this article.


Who will win Brewers vs. Reds?

Based on advanced machine learning and data, has simulated Friday's Brewers-Reds MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, currently gives the Brewers a 58% chance of beating the Reds.

More: Brewers vs. Reds Simulated 10K Times

Brewers vs. Reds Game Odds

  • Run Line: Reds +1.5 (-115), Brewers -1.5 (-102)
  • Moneyline: Reds +140, Brewers -164
  • Total: Over/Under 8.5 (-115/-104)

Run Line, Moneyline and Over/Under

The Reds are listed as +1.5 underdogs against the Brewers, with -115 at Caesars Sportsbook the best odds currently available.

For the favored Brewers (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -102.

BetMGM currently has the best moneyline odds for the Reds at +140. That means you can bet $100 to profit $140, earning a total payout of $240, if they win.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Brewers at -164, where you can risk $164 to win $100, for a total payout of $264, if they come out on top.

The Over/Under for total runs scored is set at 8.5 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while FanDuel Sportsbook currently has the best odds for the Under at -104.

As always, check out all of the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 55% chance of covering the run line, while the Over/Under total of 8.5 runs is a 54% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Brewers vs. Reds


Our best bets are based on complex simulations and wagering intelligence to help you make smarter investments with the legal sportsbooks in America.

While the Brewers are more likely to win the game, according to DimersBOT, betting on the Reds moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on is one of the keys to achieving long-term profitability.

Brewers vs. Reds Prediction

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Dimers has full coverage of Friday's Brewers-Reds matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for any changes to our betting insights before Brewers vs. Reds on Friday September 23, 2022.


Brewers vs. Reds 2022 Game Info

Friday's action between the Reds and Brewers at Great American Ball Park is scheduled to begin at 6:40PM ET.

  • Who: Milwaukee Brewers vs. Cincinnati Reds
  • Date: Friday September 23, 2022
  • Time: 6:40PM ET / 3:40PM PT
  • Venue: Great American Ball Park

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Want more MLB previews like this?

So, you liked our Brewers vs. Reds betting predictions? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB matchup as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets, which allows us to create the most authoritative MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not take a look around?

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.

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