Best MLB Betting Picks, Predictions and Parlays: Wednesday September 22, 2021

It's Wednesday in the Majors and we've got three picks for today's slate to get you going as we look to build some bank for the weekend.

It's Wednesday September 22, 2021, and, as always, we've simulated all of the day's MLB games 10,000 times each to determine where the value lies for baseball bettors across the United States.

With MLB betting picks, probabilities, odds and predicted scores featured each and every day, check out our top plays for Wednesday's MLB games by reading this article.

Today's MLB best bets and odds are proudly brought to you by Caesars Sportsbook.

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Free MLB Picks For Wednesday September 22, 2021

White Sox vs. Tigers 

BET: Tigers at the run line with Caesars (-110)

📈 54% probability

We're going back to the well for this interesting series out in Detroit that has seen the Tigers put together a nice little stretch, beating the Sox twice. We're not too sure if Chicago have decided to put their cue in the rack in preparation for the postseason, or if Detroit are simply too strong, but our data projections like them to continue their form into Wednesday with the added security of the run line representing the strongest value.

UPDATE: GAME POSTPONED

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Royals vs. Indians

BET: Royals at the moneyline with Caesars (-110)

📈 2.1% edge on the sportsbooks' odds

This will be the fourth game of a series that the Royals have had the ascendency in and we like that to continue this afternoon with the Indians trotting out one of their worst pitchers statistically in Logan Allen. Overall this season, the left-arm Allen has a 1-7 starting record to go with a 7.11 ERA. Adding to this is the penchant the Royals have for facing lefties, averaging a whopping 6.93 runs per game over their last ten when facing a left-hander. We're taking the moneyline, but the run line at +150 is also tasty for those brave enough.

MORE: Royals vs. Indians simulator

UPDATE: GAME POSTPONED

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Orioles vs. Phillies

BET: Phillies at the run line with Caesars (-140)

📈 51% probability

This looks like it could get nasty. Real nasty. The Orioles are sending Keegan Atkin out to the mound for this one. Atkin has an unenviable 2-10 record as a starter this year with a 6.93 ERA, coming up against one of the hottest teams in baseball in the Phillies. While the O's were able to snatch one game in this series on Monday night, expect things to open up tonight for Harper and co. with a dominant victory.

MORE: Orioles vs. Phillies simulator

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Mets vs. Red Sox

BET: Red Sox at the run line with Caesars (+110)

📈 2.1% edge on the sportsbooks' odds

We don't know what has happened to Taijuan Walker since the All-Star break, but it has to be one of the steepest declines we've seen in recent times. Walker has been nothing short of atrocious, going for a 7.63 ERA in his last three starts. With the Red Sox still fighting to confirm their place in the Wild Card game, we've got the pain continuing for the Mets and Walker who could be punished early.

MORE: Mets vs. Red Sox simulator

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Astros vs. Angels

BET: Total runs OVER 9.5 with Caesars (+100)

📈 52.5% probability

If you're a superstitious bettor, seeing these teams combine for 25 runs in two games this series and then looking at the probable pitcher lineup for tonight's game to see the Angels are sending out someone called Janson Junk will probably get your motor running. We're going to continue to play the Overs here with the Astros offense having their way with the Angels this week so far.

MORE: Astros vs. Angels simulator

Your game not here? Find out who we're betting on for every baseball game on Wednesday via our MLB Bet Hub, where we deliver you MLB predictions and suggested bets.

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MLB Parlay For Wednesday, September 22, 2021

🔥 Phillies -1.5
🔥 Red Sox -1.5
🔥 Astros/Angels o9.5

Parlay Odds +620

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