Best MLB Betting Picks and Parlays: Wednesday April 21, 2021

We're on a hot streak in the MLB, going 8-1 on our daily baseball plays since Sunday. What do we have in store for Wednesday's slate? 

It's Wednesday April 21, and, as always, we've simulated all of tonight's games 10,000 times each determining where the value lies for baseball bettors across the United States.

With MLB betting picks, probabilities, odds and predicted scores featured each and every day, check out our top plays for tonight's games.

Your game not here? Find out who we're betting on in every game via our MLB Bet Hub where we deliver you predictions and suggested bets, based on the edge we've identified against the sportsbooks' odds.

Just want picks? Sure thing. Visit our Quick Picks section and get the lowdown on the best bets for all pro and college sports.

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Here is what the data is telling us for today's MLB games ⏬

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Giants @ Phillies

BET: 🔥 Total runs OVER 8 with FanDuel Sportsbook (-115)

📈 56.1% probability 

We made bank on the Giants at the run line yesterday, but after a 17-run game on Tuesday, it's hard for us to ignore a total play when these two meet again on Wednesday. We'll be watching Zach Eflin for the Phillies specifically, who is listed as the probable pitcher - the over is 2-1 in games that he's featured in so far this season.

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MORE: Giants @ Phillies predictions

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Brewers @ Padres

BET: 🔥 Milwaukee Brewers at the run line (-120) with William Hill Sportsbook

📈 54.5% probability

OK, is it time to worry about San Diego? Coming up against the Dodgers on the weekend and dropping two of the three games was somewhat understandable, but after a bad 6-0 loss to the Brewers last night, have they officially lapsed into a slide? Our data thinks that might be the case and we'll be taking the Brewers run line at handy odds.

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MORE: Brewers @ Padres predictions

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Diamondbacks @ Reds

 

BET: 🔥 Total runs OVER 8.5 with BetMGM (-110)

📈 4.3% edge on the sportsbook's odds

The Reds have the best offense in the league, averaging 6.09 runs per nine inning while Arizona own one of the worst run defenses. Does 1 + 1 = 9 runs? Yes, yes it does. Look for the runs to flow in this one, according to our data projections.

MORE: Diamondbacks @ Reds predictions

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MLB Wednesday Parlay

🔥 Giants/Phillies o8 runs
🔥 Brewers +1.5
🔥 D-Backs/Reds o8.5 runs

💰 Parlay @ FanDuel Sportsbook (+551) 

MORE PICKS:

 
🏀 READ: NBA WEDNESDAY PICKS
🏀 READ: WEDNESDAY PROP PICKS
🏒 READ: NHL WEDNESDAY PICKS
💰 READ: WEDNESDAY'S PERFECT PARLAY

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