Best bets today for all sports: Wednesday's picks include San Luis vs. Pumas UNAM Liga MX play [10/22/2025]

Today’s sports betting picks for October 22, 2025 are here, with Wednesday’s best bets fueled by thousands of data simulations analyzing the latest odds and matchups.

These best bets come from a range of sports events scheduled over the next 24 hours, with Liga MX in our sights as an inviting betting opportunity.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, October 22, 2025, including our complete set of picks and best bets for today and the week ahead.

Starting Thursday, October 23, most of our pre-game editorial content — including articles like this one — will move exclusively to Dimers Pro.

To keep accessing these insights, use the promo code UPGRADE at checkout for $100 off an annual subscription. That means you can get a full year of Dimers Pro for just $99.99 (normally $199.99).

List of best bets for today [10/22, updated 11:02PM ET]

After crunching the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best bet for Wednesday, October 22, 2025.

Liga MX: Pumas UNAM ML (-110)

• Probability: 55.5%
• Edge: 3.1%
• Liga MX matchup: San Luis vs. Pumas UNAM (11:05PM ET, Wednesday)

Our model has pinpointed a high-probability betting opportunity today, which comes in the San Luis vs. Pumas UNAM matchup in Liga MX. We recommend a bet on Pumas UNAM ML at -110 odds, with our analysis showing a 55.5% chance of hitting and a compelling edge of 3.1%.

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's picks is a -105 over/under bet with a 5.6% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 22, 2025.

List of upcoming matchups to bet on now [10/22/2025]

• Liga MX: San Luis vs. Pumas UNAM (11:05PM ET, Wednesday)
• Tennis: Jaqueline Cristian vs. Ekaterina Alexandrova (12:10AM ET, Thursday)
• Tennis: Ann Li vs. Camila Osorio (1:00AM ET, Thursday)
• Tennis: Elisabetta Cocciaretto vs. Xiyu Wang (2:10AM ET, Thursday)
• Tennis: Ajla Tomljanovic vs. Catherine McNally (2:10AM ET, Thursday)
• Tennis: Yulia Putintseva vs. Ella Seidel (3:20AM ET, Thursday)
• Tennis: Anna Bondar vs. Claire Liu (3:20AM ET, Thursday)
• Tennis: Cameron Norrie vs. Matteo Berrettini (6:00AM ET, Thursday)
• Tennis: Veronika Erjavec vs. Shuai Zhang (7:00AM ET, Thursday)
• Tennis: Denis Shapovalov vs. Valentin Royer (7:10AM ET, Thursday)

Conclusion

Our best bets are locked and loaded for October 22, 2025, featuring plays such as Pumas UNAM ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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