Best bets today for all sports: Tuesday's picks include Santos Laguna vs. Mazatlan Liga MX play [10/21/2025]

Today’s sports betting picks for October 21, 2025 are here, with Tuesday’s best bets built on tens of thousands of predictive simulations analyzing the latest odds and matchups.

These best bets come from a range of sports events scheduled over the next 24 hours, with Liga MX standing out as an attractive sport to bet on.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Tuesday, October 21, 2025, including our complete set of picks and best bets for today and the week ahead.

Starting Thursday, October 23, most of our pre-game editorial content — including articles like this one — will move exclusively to Dimers Pro.

To keep accessing these insights, use the promo code UPGRADE at checkout for $100 off an annual subscription. That means you can get a full year of Dimers Pro for just $99.99 (normally $199.99).

List of best bets for today [10/21, updated 10:31PM ET]

After digging deep into the numbers and conducting thousands of simulations, our independent predictive analytics model has identified the best bets for Tuesday, October 21, 2025.

Liga MX: Santos Laguna vs. Mazatlan under 2.5 goals (+120)

• Probability: 53.8%
• Edge: 8.4%
• Liga MX matchup: Santos Laguna vs. Mazatlan (11:00PM ET, Tuesday)

Our model has pinpointed a high-probability betting opportunity today, which comes in the Santos Laguna vs. Mazatlan game in Liga MX. We recommend an over/under bet on under 2.5 goals at +120 odds, with our analysis showing a 53.8% chance of hitting and a compelling edge of 8.4%.

Liga MX: Mazatlan ML (+110)

• Probability: 51%
• Edge: 3.4%
• Liga MX matchup: Santos Laguna vs. Mazatlan (11:00PM ET, Tuesday)

Our model has found another strong bet for Tuesday's sports action, again in the Liga MX game between Santos Laguna and Mazatlan. We suggest placing a wager on Mazatlan ML at +110 odds, with a 51% probability delivering a 3.4% edge.

Best sports bets today: Tuesday, 10/21/2025

As of 10:31PM ET, here are our top two bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Santos Laguna vs. Mazatlan (Liga MX)	Under 2.5 Goals	+120 @ FanDuel	53.8%	8.4%
Santos Laguna vs. Mazatlan (Liga MX)	Mazatlan ML	+110 @ DraftKings	51%	3.4%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's picks is a -130 over/under bet with a 9.6% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 21, 2025.

List of upcoming sports to bet on right now [10/21/2025]

• Tennis: Eva Lys vs. Victoria Mboko (10:40PM ET, Tuesday)
• Liga MX: Santos Laguna vs. Mazatlan (11:00PM ET, Tuesday)
• Liga MX: Juarez vs. Monterrey (11:05PM ET, Tuesday)
• Tennis: Anna Kalinskaya vs. Diana Shnaider (11:50PM ET, Tuesday)
• Tennis: Ann Li vs. Camila Osorio (1:00AM ET, Wednesday)
• Tennis: Elisabetta Cocciaretto vs. Xiyu Wang (3:20AM ET, Wednesday)
• Tennis: Karolina Muchova vs. Maya Joint (4:00AM ET, Wednesday)
• Tennis: Jiri Lehecka vs. Botic Van de Zandschulp (6:00AM ET, Wednesday)
• Tennis: Veronika Erjavec vs. Shuai Zhang (7:00AM ET, Wednesday)
• Tennis: Ugo Humbert vs. Sebastian Korda (7:10AM ET, Wednesday)

Conclusion

Our best bets are locked and loaded for October 21, 2025, featuring plays such as under 2.5 goals in the Santos Laguna vs. Mazatlan matchup and Mazatlan ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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