Best bets today for all sports: Saturday's picks include San Jose State vs. San Diego State college football play [11/22/2025]

Today’s best sports bets for November 22, 2025 are here, with San Jose State vs. San Diego State in college football and Northern Iowa vs. UC Irvine in men's college basketball among the top plays identified by our model across Saturday’s action.

Dimers’ predictive analytics engine runs 24/7, searching the latest odds to uncover legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of best bets for today [11/22, updated 10:04PM ET]

Below, you’ll find today’s top 10 bets, ranked by edge for Saturday, November 22, 2025.

College Football: San Jose State ML (+310)

• Edge: 2.9%
• Probability: 27.3%
• College Football matchup: San Jose State vs. San Diego State (10:30PM ET, Saturday)

Our model has identified value on San Jose State to defeat San Diego State at +310 odds. A 27.3% probability produces an edge of 2.9%, making this the strongest play for today's sports action.

Men's College Basketball: UC Irvine ML (-142)

• Edge: 2.9%
• Probability: 61.6%
• College Football matchup: Northern Iowa vs. UC Irvine (10:30PM ET, Saturday)

UC Irvine ML carries a 2.9% edge and a probability of 61.6% at -142 odds, according to our model.

College Football: San Jose State +10.5 (-110)

• Edge: 2.2%
• Probability: 54.6%
• College Football Matchup: San Jose State vs. San Diego State (10:30PM ET, Saturday)

San Jose State +10.5 vs. San Diego State at -110 odds shows a 2.2% edge, supported by a 54.6% probability in simulations.

NFL: Cardinals +2.5 (-110)

• Edge: 5.8%
• Probability: 58.2%
• NFL Matchup: Jaguars vs. Cardinals (4:05PM ET, Sunday)

A 5.8% edge and 58.2% probability make Cardinals +2.5 vs. Jaguars at a value play in the Jaguars vs. Cardinals matchup, per our model.

MLS: Cincinnati ML (+190)

• Edge: 5.5%
• Probability: 40%
• MLS Matchup: Miami vs. Cincinnati (5:00PM ET, Sunday)

Cincinnati ML at +190 odds presents a 5.5% edge, with simulations resulting in a probability of 40%.

Men's College Basketball: Georgia +2.5 (-118)

• Edge: 4.6%
• Probability: 58.7%
• Men's College Basketball Matchup: Clemson vs. Georgia (1:00PM ET, Sunday)

Our model finds value on Georgia +2.5 at -118 odds, supported by an edge of 4.6%.

NBA: Trail Blazers +15.5 (-110)

• Edge: 4.4%
• Probability: 56.8%
• NBA Matchup: Trail Blazers vs. Thunder (7:00PM ET, Sunday) Our model has uncovered value on Trail Blazers +15.5 at -110 odds. A 56.8% probability produces a 4.4% edge, making this a strong play for today's NBA action.

NBA: Nets +13.5 (-106)

• Edge: 4.3%
• Probability: 55.8%
• NBA Matchup: Nets vs. Raptors (6:00PM ET, Sunday)

A 4.3% edge on a 55.8% probability makes Nets +13.5 at -106 odds a solid value play in today's Nets vs. Raptors matchup.

NFL: Giants vs. Lions under 50.5 points (-105)

• Edge: 4.2%
• Probability: 55.4%
• NFL Matchup: Giants vs. Lions (1:00PM ET, Sunday)

Our model projects value on under 50.5 points at -105 odds. A 55.4% probability produces a 4.2% edge, making the under the favorable side in Saturday’s NFL matchup.

La Liga: Elche ML (+700)

• Edge: 4.1%
• Probability: 16.6%
• La Liga Matchup: Real Madrid vs. Elche (3:00PM ET, Sunday)

Rounding out our top 10 bets, Elche to defeat Real Madrid at +700 odds shows a 16.6% probability and a 4.1% edge.

Best sports bets today summary: Saturday, 11/22/2025

As of 10:04PM ET, here are our top bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
San Jose State vs. San Diego State (College Football)	San Jose State ML	+310 @ BetMGM	2.9%	27.3%
Northern Iowa vs. UC Irvine (Men's College Basketball)	UC Irvine ML	-142 @ DraftKings	2.9%	61.6%
San Jose State vs. San Diego State (College Football)	San Jose State +10.5	-110 @ BetMGM	2.2%	54.6%
Jaguars vs. Cardinals (NFL)	Cardinals +2.5	-110 @ FanDuel	5.8%	58.2%
Miami vs. Cincinnati (MLS)	Cincinnati ML	+190 @ FanDuel	5.5%	40%
Clemson vs. Georgia (Men's College Basketball)	Georgia +2.5	-118 @ DraftKings	4.6%	58.7%
Trail Blazers vs. Thunder (NBA)	Trail Blazers +15.5	-110 @ BetMGM	4.4%	56.8%
Nets vs. Raptors (NBA)	Nets +13.5	-106 @ FanDuel	4.3%	55.8%
Giants vs. Lions (NFL)	Under 50.5 Points	-105 @ DraftKings	4.2%	55.4%
Real Madrid vs. Elche (La Liga)	Elche ML	+700 @ FanDuel	4.1%	16.6%

List of upcoming events to bet on right now [11/22/2025]

• NCAAF: Utah State vs. Fresno State (10:30PM ET, Saturday)
• NCAAF: San Jose State vs. San Diego State (10:30PM ET, Saturday)
• NCAAF: Washington vs. UCLA (10:30PM ET, Saturday)
• NCAAM: Northern Iowa vs. UC Irvine (10:30PM ET, Saturday)
• NCAAW: Texas A&M vs. Virginia Commonwealth (11:30PM ET, Saturday)
• La Liga: Rayo Vallecano vs. Real Oviedo (8:00AM ET, Sunday)
• EPL: Aston Villa vs. Leeds (9:00AM ET, Sunday)
• La Liga: Girona vs. Real Betis (10:15AM ET, Sunday)
• EPL: Tottenham vs. Arsenal (11:30AM ET, Sunday)
• La Liga: Atletico Madrid vs. Getafe (12:30PM ET, Sunday)

Conclusion

Our best bets are locked and loaded for November 22, 2025, featuring plays such as San Jose State ML and UC Irvine ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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